Table 3 Analytes (Serum Proteins) correlated with baseline MRI-PDFF, ALT and AST and reversed with Clesacostat treatment.

From: SomaLogic proteomics reveals new biomarkers and provides mechanistic, clinical insights into Acetyl coA Carboxylase (ACC) inhibition in Non-alcoholic Steatohepatitis (NASH)

Target name	Entrez gene symbol	PF-05221304 25 mg		Placebo		Wilcoxon P-value	Adjusted P-Value
Target name	Entrez gene symbol	Median change from baseline (%)	Median absolute deviation	Median change from baseline (%)	Median absolute deviation	Wilcoxon P-value	Adjusted P-Value
Beta-hexosaminidase subunit beta	HEXB	− 20.8679623	12.49713	− 5.49241866	10.79133	5.79E − 06	0.001902
Beta-glucuronidase	GUSB	− 26.6295838	16.45261	− 3.884524	12.34694	6.16E − 06	0.001939
Acid sphingomyelinase-like phosphodiesterase 3a	SMPDL3A	− 15.3223264	11.89456	4.743605763	19.30132	5.50E − 05	0.011239
Cathepsin Z	CTSZ	− 14.7902944	6.598115	− 3.12465181	9.407973	0.000109	0.018288
Alcohol dehydrogenase 1C	ADH1C	− 45.9628869	23.89188	− 10.9384928	51.6577	0.003378	0.225952
Fructose-1,6-bisphosphatase 1	FBP1	− 34.7420965	21.08113	− 6.46549402	37.46839	0.004403	0.277359
Aldo–keto reductase family 1 member C4	AKR1C4	− 43.4955138	25.62926	− 14.7585336	42.22398	0.005494	0.312276
UDP-glucose 6-dehydrogenase	UGDH	− 58.7810965	25.10112	− 35.5491113	26.62759	0.00635	0.324314
Alcohol dehydrogenase 1A	ADH1A	− 36.4063579	28.85745	− 8.76791611	34.74184	0.010002	0.383436
Triggering receptor expressed on myeloid cells 2	TREM2	− 16.7887361	17.58957	− 7.2378576	9.816764	0.009667	0.383436
Receptor-type tyrosine-protein phosphatase eta	PTPRJ	4.153921567	12.44759	− 2.61114164	8.006481	0.009341	0.383436
UDP-N-acetylhexosamine pyrophosphorylase	UAP1	− 12.5382394	12.92635	− 4.03576294	11.87616	0.011836	0.410402
3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	− 23.7183492	30.55905	− 2.48128154	35.04226	0.013072	0.43339
Glutathione S-transferase A1	GSTA1	− 33.9278347	24.08301	− 13.1034067	38.11414	0.013958	0.445173
Beta-enolase	ENO3	4.631616769	5.875611	− 1.00980993	7.680723	0.01442	0.448553
Glutathione S-transferase A1	GSTA1	− 22.5875907	20.99155	− 7.12367017	28.7786	0.015384	0.465142
Apolipoprotein F	APOF	7.609307386	29.26644	− 10.6897007	21.73069	0.020446	0.498164
Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	− 27.3186611	27.87644	− 11.4345456	33.93161	0.019212	0.498164
Aldehyde dehydrogenase, mitochondrial	ALDH2	− 39.1473008	23.23401	− 21.1066663	28.49847	0.021088	0.498164
Retinol-binding protein 5	RBP5	− 21.5527005	19.96617	0.580391731	27.24665	0.019821	0.498164
NADPH–cytochrome P450 reductase	POR	− 20.1967049	32.1379	− 0.91256684	26.14082	0.019821	0.498164
Homogentisate 1,2-dioxygenase	HGD	− 31.7686512	26.89073	− 11.9703555	30.8528	0.021748	0.498164
Enoyl-CoA hydratase, mitochondrial	ECHS1	− 41.3007318	17.68261	− 5.12752271	58.0568	0.023121	0.511022
Protein CREG1	CREG1	− 10.4380771	14.23274	− 2.02811707	7.097584	0.029377	0.555161
Fumarylacetoacetase	FAH	− 17.7465088	21.43313	− 5.1444015	19.99072	0.034965	0.580882
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	− 17.3640523	12.27795	− 9.94417577	13.87492	0.04259	0.612047
S-adenosylmethionine synthase isoform type-1	MAT1A	− 44.7168152	27.65514	− 24.1158714	29.61752	0.046258	0.640415

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Table 3 Analytes (Serum Proteins) correlated with baseline MRI-PDFF, ALT and AST and reversed with Clesacostat treatment.

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