Table 4 Analytes (Serum Proteins) significantly increased with Clesacostat treatment.

From: SomaLogic proteomics reveals new biomarkers and provides mechanistic, clinical insights into Acetyl coA Carboxylase (ACC) inhibition in Non-alcoholic Steatohepatitis (NASH)

Target name

Entrez gene symbol

PF-05221304 25 mg

Placebo

Wilcoxon P-value

Adjusted P-Value

Median change from baseline (%)

Median absolute deviation

Median change from baseline (%)

Median absolute deviation

Apolipoprotein C-III

APOC3

74.7334611

96.57551

− 1.73678423

30.70269

5.38E − 09

6.77E − 06

Protein Wnt-5a

WNT5A

47.8020532

37.6666

− 5.5039594

22.16414

1.86E − 10

4.69E − 07

Tumor protein p53-inducible protein 11

TP53I11

44.1513061

57.14137

− 22.8730695

24.49742

9.98E − 07

0.000503

Centromere/kinetochore protein zw10 homolog

ZW10

38.1656684

30.97409

15.20723472

23.84159

8.41E − 05

0.015127

Apolipoprotein E (isoform E4)

APOE

37.709568

35.88046

− 0.0210439

17.44359

2.54E − 05

0.006405

Pre-miRNA 5'-monophosphate methyltransferase

BCDIN3D

36.9730449

44.17851

− 9.1862192

26.85252

1.43E − 07

9.01E − 05

PCNA-associated factor

PCLAF

35.3876222

31.54175

14.90628444

19.50688

4.94E − 05

0.010369

Anterior gradient protein 3

AGR3

31.3689907

47.65088

− 3.18661332

34.6531

0.000103

0.017767

Apolipoprotein E (isoform E3)

APOE

25.6186986

37.44934

− 10.5408351

13.05814

4.10E − 08

3.10E − 05

Chitinase-3-like protein 1

CHI3L1

25.5469828

50.9453

− 6.84243776

17.47749

0.00014

0.022104

Reticulon-1

RTN1

25.0343247

15.17332

4.592733367

9.875374

1.31E − 06

0.000619

Apolipoprotein E

APOE

24.6261041

73.81208

− 26.7587525

17.97165

4.97E − 07

0.000289

Ferritin, mitochondrial

FTMT

23.6934013

29.66658

− 5.64378155

22.33269

5.44E − 06

0.001869

BTB/POZ domain-containing protein KCTD2

KCTD2

22.7217126

42.03258

− 6.34590928

17.68129

0.000199

0.029463

Protein CEI

C5orf38

22.0208358

29.02985

− 9.79043932

23.97688

9.25E − 10

1.40E − 06

Apolipoprotein E (isoform E2)

APOE

21.3615186

20.85952

3.3782439

10.12542

0.000103

0.017767

Protein BRICK1

BRK1

21.1635959

15.84644

− 0.65559379

17.41062

3.36E − 05

0.008203

Transmembrane and coiled-coil domains protein 3:region 1

TMCC3

20.4146804

26.83979

− 2.21164738

14.91316

1.80E − 05

0.00505

Quinone oxidoreductase-like protein 1

CRYZL1

20.1997676

33.054

− 17.3060285

18.41901

4.10E − 08

3.10E − 05

Kazal-type serine protease inhibitor domain-containing protein 1

KAZALD1

18.9703774

8.886351

− 5.12416119

11.99074

5.14E − 11

3.89E − 07

Coiled-coil-helix-coiled-coil-helix domain-containing protein 7

CHCHD7

18.9153249

29.24723

− 8.49171334

14.05904

9.03E − 08

6.21E − 05

Properdin

CFP

18.1115552

17.01554

− 2.47647189

19.13364

0.000171

0.025917

Retinol dehydrogenase 10

RDH10

17.8993559

14.39677

2.165969642

9.917509

3.08E − 06

0.001225

Hemoglobin subunit theta-1

HBQ1

17.0209795

26.12728

− 13.9692047

17.36606

4.21E − 10

7.96E − 07

Semaphorin-4G

SEMA4G

16.2895315

13.4321

− 2.50608801

10.66848

6.55E − 06

0.00198

Neurexophilin-3

NXPH3

15.7475474

11.28494

− 2.69334875

8.740806

1.36E − 10

4.69E − 07

DCN1-like protein 5

DCUN1D5

14.7075867

22.86336

− 11.5991541

12.36273

1.18E − 08

1.27E − 05

Cysteine-rich protein 1

CRIP1

14.0620225

21.71555

− 5.4970607

13.07966

8.41E − 05

0.015127

Cytochrome P450 3A4

CYP3A4

13.2007534

19.88569

− 0.93053799

10.38937

0.000266

0.037937

Transferrin receptor protein 1:Extracellular domain

TFRC

11.8112646

11.02555

0.190242158

9.385641

7.18E − 05

0.014283

Cyclic AMP-dependent transcription factor ATF-6 beta

ATF6B

9.29288772

13.27761

− 5.87521091

9.96803

1.40E − 06

0.000623

ADP-ribosylation factor GTPase-activating protein 1

ARFGAP1

8.91451889

21.6919

− 13.1357897

18.82623

3.56E − 05

0.0084

Semaphorin-6C

SEMA6C

8.50861234

14.70416

− 4.46834039

10.53604

4.94E − 05

0.010369

Cytidine deaminase

CDA

7.70013125

17.21845

− 13.36951

11.56769

7.07E − 07

0.000382

Eyes absent homolog 2

EYA2

6.83742311

11.6176

− 4.27677377

9.700987

3.76E − 05

0.008608

Rho GTPase-activating protein 26

ARHGAP26

6.35777932

11.9962

− 2.53658746

7.482853

0.000266

0.037937

Keratin, type I cytoskeletal 19

KRT19

6.15383427

18.3018

− 9.39798058

13.67294

0.000279

0.039062

Prostasin

PRSS8

5.61009802

9.776063

− 3.72069492

9.680681

0.000163

0.025163

Dehydrogenase/reductase SDR family member 9

DHRS9

5.60561948

6.939527

− 0.79908175

7.157673

0.000133

0.021464

RAC-beta serine/threonine-protein kinase

AKT2

5.18489283

9.143634

− 2.62771759

7.096422

4.19E − 05

0.009325

Lymphocyte activation gene 3 protein

LAG3

4.53640683

12.79597

− 9.44912474

12.14505

7.98E − 05

0.015074

C4b-binding protein alpha chain

C4BPA

3.84384914

18.75151

− 9.81137513

9.128242

0.000354

0.046093

Acidic leucine-rich nuclear phosphoprotein 32 family member A

ANP32A

3.46931509

9.533871

− 7.11391914

10.94499

0.000307

0.042187

Mitochondrial import inner membrane translocase subunit Tim13

TIMM13

3.28611503

17.95397

− 10.9589149

10.34811

0.000388

0.049756

Prenylcysteine oxidase 1

PCYOX1

1.72624515

13.02383

− 8.54629889

8.339425

7.57E − 05

0.01467

Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

POMGNT2

1.55999183

8.087636

− 17.2116013

12.38865

1.40E − 08

1.32E − 05

Cyclic AMP-dependent transcription factor ATF-5

ATF5

0.24059968

10.53402

− 11.6675671

11.53376

4.51E − 06

0.001623

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