Table 5 Analytes (Serum Proteins) significantly decreased with Clesacostat treatment.
Target name | Entrez gene symbol | PF-05221304 25 mg | Placebo | Wilcoxon P-value | Adjusted P-Value | ||
|---|---|---|---|---|---|---|---|
Median change from baseline (%) | Median absolute deviation | Median change from baseline (%) | Median absolute deviation | ||||
Beta-glucuronidase | GUSB | − 26.6295838 | 16.45261 | − 3.884524 | 12.34694 | 6.16E − 06 | 0.001939 |
Beta-hexosaminidase subunit beta | HEXB | − 20.8679623 | 12.49713 | − 5.49241866 | 10.79133 | 5.79E − 06 | 0.001902 |
GDH/6PGL endoplasmic bifunctional protein | H6PD | − 19.5315762 | 13.87645 | − 3.74835017 | 11.02237 | 3.28E − 06 | 0.001241 |
Acid sphingomyelinase-like phosphodiesterase 3a | SMPDL3A | − 15.3223264 | 11.89456 | 4.743605763 | 19.30132 | 5.50E − 05 | 0.011239 |
Cathepsin Z | CTSZ | − 14.7902944 | 6.598115 | − 3.12465181 | 9.407973 | 0.000109 | 0.018288 |
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial | OXSM | − 11.5482148 | 14.44077 | 7.335706562 | 24.49535 | 0.000354 | 0.046093 |
Endoplasmic reticulum aminopeptidase 1 | ERAP1 | − 9.80165592 | 5.926097 | 0.127660424 | 10.25061 | 2.02E − 05 | 0.005276 |
Secretoglobin family 3A member 1 | SCGB3A1 | − 9.3811058 | 15.87089 | 5.03582545 | 16.32092 | 0.000121 | 0.019815 |
Coagulation factor IXab | F9 | − 7.32784606 | 3.828303 | − 14.6869178 | 4.91432 | 2.38E − 06 | 0.000999 |
Coagulation factor IX | F9 | − 4.82130905 | 6.649734 | − 10.893273 | 4.624268 | 1.06E − 05 | 0.003091 |
Glutamate receptor 4 | GRIA4 | − 4.02864529 | 14.14756 | − 13.3450746 | 10.48474 | 0.000337 | 0.045545 |
Eukaryotic elongation factor 2 kinase | EEF2K | − 2.13108471 | 12.45974 | − 12.9271585 | 14.26788 | 2.02E − 05 | 0.005276 |
