Table 2 Multiple linear regression table of n = 43 participants with cognitive tests as dependent variables.

From: Predicting performance in attention by measuring key metabolites in the PCC with 7T MRS

	Glutamate		Glutamine		GABA		Myo-Inositol		Aspartate
TMT A	B	− 3.565	B	− 5.002	B	− 1.467	B	− 8.837	B	− 8.600
	SE B	2.356	SE B	3.805	SE B	8.701	SE B	3.044	SE B	5.716
	β	− 0.238	β	− 0.219	β	− 0.028	β	− 0.431	β	− 0.229
	p (CE)	0.138	p (CE)	0.196	p (CE)	0.867	p (CE)	0.006	p (CE)	0.140
	p (BS)	0.226	p (BS)	0.336	p (BS)	0.832	p (BS)	0.008	p (BS)	0.120
	Bootstrap CI	(− 10.298) − (1.706)	Bootstrap CI	(− 14.094) − (4.284)	Bootstrap CI	(− 17.335) − (12.883)	Bootstrap CI	(− 14.994) − (− 3.468)	Bootstrap CI	(− 20.610) − (0.853)
TMT B	B	− 6.410	B	− 3.717	B	− 15.285	B	− 15.207	B	− 8.998
	SE B	4.287	SE B	7.043	SE B	16.447	SE B	5.596	SE B	10.591
	β	− 0.237	β	− 0.090	β	− 0.155	β	− 0.411	β	− 0.133
	p (CE)	0.143	p (CE)	0.601	p (CE)	0.358	p (CE)	0.010	p (CE)	0.401
	p (BS)	0.224	p (BS)	0.590	p (BS)	0.296	p (BS)	0.027	p (BS)	0.310
	Bootstrap CI	(− 17.782) − (2.461)	Bootstrap CI	(− 17.557) − (9.887)	Bootstrap CI	(− 47.505) − (15.557)	Bootstrap CI	(− 28.408) − (− 3.212)	Bootstrap CI	(− 28.641) − (7.713)
Alertness without signal Median	B	− 8.267	B	− 3.794	B	2.268	B	− 1.764	B	− 31.413
	SE B	7.109	SE B	11.713	SE B	27.334	SE B	9.873	SE B	16.578
	β	− 0.181	β	− 0.055	β	0.014	β	− 0.029	β	− 0.281
	p (CE)	0.252	p (CE)	0.748	p (CE)	0.934	p (CE)	0.859	p	0.066
	p (BS)	0.282	p (BS)	0.688	p (BS)	0.936	p (BS)	0.882	Bootstrap p	0.070
	Bootstrap CI	(− 22.994) − (8.135)	Bootstrap CI	(− 25.461) − (15.289)	Bootstrap CI	(− 47.127) − (47.575)	Bootstrap CI	(− 20.740) − (20.730)	Boostrap CI	(− 64.486) − (3.301)
Alertness without Signal SD	B	− 0.934	B	− 6.460	B	19.719	B	2.347	B	− 17.996
	SE B	3.466	SE B	5.530	SE B	12.699	SE B	4.723	SE B	7.795
	β	− 0.044	β	− 0.205	β	0.257	β	0.083	β	− 0.349
	p (CE)	0.789	p (CE)	0.250	p (CE)	0.129	p (CE)	0.622	p (CE)	0.026
	p (BS)	0.816	p (BS)	0.319	p (BS)	0.199	p (BS)	0.540	p (BS)	0.096
	Bootstrap CI	(− 8.366) − (6.477)	Bootstrap CI	(− 18.639) − (4.730)	Bootstrap CI	(− 9.258) − (45.402)	Bootstrap CI	(− 5.799) − (10.024)	Bootstrap CI	(− 39.912) − (0.604)
Alertness with Signal Median	B	− 0.008	B	0.221	B	4.990	B	4.808	B	− 16.867
	SE B	5.197	SE B	8.609	SE B	19.713	SE B	7.097	SE B	12.289
	β	0.000	β	0.005	β	0.043	β	0.111	β	− 0.215
	p (CE)	0.999	p (CE)	0.980	p (CE)	0.802	p (CE)	0.502	p (CE)	0.178
	p (BS)	1.000	p (BS)	0.978	p (BS)	0.757	p (BS)	0.523	p (BS)	0.193
	Bootstrap CI	(− 10.321) − (11.148)	Bootstrap CI	(− 16.648) − (17.002)	Bootstrap CI	(− 27.895) − (40.711)	Bootstrap CI	(− 8.145) − (21.535)	Bootstrap CI	(− 43.818) − (5.518)
Alertness with signal SD	B	− 3.814	B	− 1.158	B	12.113	B	1.710	B	− 7.175
	SE B	3.407	SE B	5.611	SE B	12.865	SE B	4.719	SE B	8.212
	β	− 0.179	β	− 0.036	β	0.157	β	0.060	β	− 0.138
	p (CE)	0.270	p (CE)	0.838	p (CE)	0.352	p (CE)	0.719	p (CE)	0.388
	p (BS)	0.242	p (BS)	0.855	p (BS)	0.145	p (BS)	0.658	p (BS)	0.421
	Bootstrap CI	(− 10.123) − (3.002)	Bootstrap CI	(− 13.608) − (11.409)	Bootstrap CI	(− 6.577) − (27.184)	Bootstrap CI	(− 5.377) − (9.011)	Bootstrap CI	(− 24.783) − (9.133)
Phasic Alertness	B	− 0.033	B	− 0.052	B	0.000	B	− 0.014	B	− 0.026
	SE B	0.019	SE B	0.032	SE B	0.076	SE B	0.027	SE B	0.048
	β	− 0.271	β	− 0.284	β	0.001	β	− 0.085	β	− 0.087
	p (CE)	0.096	p (CE)	0.106	p (CE)	0.995	p (CE)	0.615	p (CE)	0.589
	p (BS)	0.066	p (BS)	0.077	p (BS)	0.997	p (BS)	0.562	p (BS)	0.626
	Bootstrap CI	(− 0.073) − (0.004)	Bootstrap CI	(− 0.106) − (0.003)	Bootstrap CI	(− 0.153) − (0.131)	Bootstrap CI	(− 0.054) − (0.042)	Bootstrap CI	(− 0.109) − (0.108)
Go/No-go Mean	B	1.681	B	− 10.977	B	35.879	B	11.868	B	− 72.405
	SE B	14.224	SE B	23.006	SE B	53.229	SE B	19.337	SE B	32.050
	β	0.019	β	− 0.083	β	0.113	β	0.100	β	− 0.337
	p (CE)	0.907	p (CE)	0.636	p (CE)	0.504	p (CE)	0.543	p (CE)	0.030
	p (BS)	0.924	p (BS)	0.608	p (BS)	0.553	p (BS)	0.548	p (BS)	0.097
	Bootstrap CI	(− 32.058) − (34.624)	Bootstrap CI	(− 51.117) − (28.221)	Bootstrap CI	(− 78.132) − (145.463)	Bootstrap CI	(− 34.618) − (51.005)	Bootstrap CI	(− 157.084) − (0.542)
Go/No-go Mistakes	B	− 0.143	B	0.176	B	0.032	B	− 0.177	B	1.808
	SE B	0.285	SE B	0.462	SE B	1.077	SE B	0.389	SE B	0.620
	β	− 0.082	β	0.068	β	0.005	β	0.389	β	0.426
	p (CE)	0.619	p (CE)	0.705	p (CE)	0.976	p (CE)	0.653	p (CE)	0.006
	p (BS)	0.604	p (BS)	0.721	p (BS)	0.982	p (BS)	0.615	p (BS)	0.008
	Bootstrap CI	(− 0.733) − (0.482)	Bootstrap CI	(− 0.665) − (1.166)	Bootstrap CI	(− 2.190) − (2.638)	Bootstrap CI	(− 0.948) − (0.617)	Bootstrap CI	(0.525) − (2.998)

The independent variables are each individual metabolite, age and gender. The values for the covariates age and gender are not represented in this table because they were of no interest. Cognitive tests: TMT A = Trail Making Test A; TMT B = Trail Making Test B; Alertness without signal median = median reaction time of alertness task without signal; Alertness without signal SD = standard deviation of alertness without signal; Alertness with signal median = median reaction time of alertness task with signal; Alertness with signal SD = standard deviation of alertness with signal; Go/No-go mean = Mean of the reaction time in the Go/No-go task; Go/No-go mistakes = Number of Mistakes in the Go/No-go task. Metabolites: Asp = aspartate; Myo-Ins = myo-inositol; Glu = glutamate; Gln = glutamine; GABA = gamma aminobutyric acid. Covariate table with values of metabolites: B = unstandardised beta; SE B = standard error beta; β = beta, standardized coefficient; p(CE) = p value of metabolite coefficient. Values for bootstrapping: p(BS) = p after the bootstrapping; BS CI = lower and upper 95% confidence interval value of bootstrapping. * = p < 0.05; ** = p < 0.01.
Significant values are in bold.

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Table 2 Multiple linear regression table of n = 43 participants with cognitive tests as dependent variables.

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