Figure 4 | Scientific Reports

Figure 4

From: Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo

Figure 4

CVC, MMP1 and CVC + MMP1 treatment decreased normalized liver weights and improved liver function in vivo in CCl4-induced acute liver injury mouse model. (A) Schematic overview of the in vivo study. (B) Liver weights (respective to body weight) expressed in percentage. (C) Total alanine transaminase (ALT) plasma levels expressed in units (U)/L. (D) Total aspartate transaminase (AST) plasma levels expressed in units (U)/L. The data are represented as mean + SEM. Multiple comparisons between different groups (n = 6–7 mice per group) were performed using one-way analysis of variance (ANOVA) with a Bonferroni post hoc test. The differences were considered significant when *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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