Figure 5 | Scientific Reports

Figure 5

From: Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo

Figure 5

CVC + MMP1 treatment attenuated macrophage infiltration and liver inflammation in vivo in CCl4-induced acute liver injury mouse model. (A) Representative images (scalebar = 250 µm) of F4/80-stained liver sections. (B) Quantified positive stained area of F4/80 staining. (C) Relative mRNA expression (normalized to 18S rRNA) of Adgre1 (F4/80) and Tnfα (relative to vehicle control). The data are represented as mean + SEM. Multiple comparisons between different groups (n = 6–7 mice per group) were performed using one-way analysis of variance (ANOVA) with a Bonferroni post hoc test. The differences were considered significant when *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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