Figure 7 | Scientific Reports

Figure 7

From: Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo

Figure 7

CVC + MMP1 treatment ameliorated liver fibrogenesis in vivo in CCl4-induced acute liver injury mouse model. (A) Representative images (scalebar = 250 µm) of collagen I-stained liver sections. (B) Quantified positive stained area of collagen-I staining. (C) Relative mRNA expression (normalized to 18S rRNA) of Procollagen 1α1 (collagen I) and Acta 2 (α-SMA) (relative to vehicle control). The data are represented as mean + SEM. Multiple comparisons between different groups (n = 6–7 mice per group) were performed using one-way analysis of variance (ANOVA) with a Bonferroni post hoc test. The differences were considered significant when *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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