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Figure 2

From: In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human

Figure 2

Modulators of spontaneous hPSC-CM beats. (A) Spontaneous hPSC-CM beating intervals after the last sinus beat for increasing hPSC-CM population heterogeneity across 3 infarct stages and 3 scar sizes (27 cases in total); dark shades indicate faster beating. (B) Action potentials of infarcted cells from dense (solid lines) and sparse (dotted lines) hPSC-CM areas with the most heterogeneous hPSC-CM population in medium-sized acute (green) and chronic (purple) MI; left (LV) and right (RV) ventricle indicated. (C) Effect of sinus heart rate on spontaneous hPSC-CM beats. Left: Single cell action potential and sarcoplasmic reticulum calcium deposit of ventricular-like hPSC-CM. Right: hPSC-CM beating intervals in single cell ventricular, atrial and nodal-like hPSC-CM phenotypes (0D) and coupled in the medium scar biventricular model with the most heterogeneous population in acute MI (3D). Spontaneous single cell atrial and nodal-like hPSC-CMs beating exceeded pacing below 60 and 100 bpm, respectively.

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