Figure 4

2D interactions of docking 6-gingerol with DNMT1 (A), DNMT3A (B), and DNMT3B (C) by Ligplot+. The results indicate that 6-gingerol, the active ingredient, can form multiple chemical bonds with the enzymes, including hydrogen and hydrophobic bonds. This demonstrates the potential effect of 6-gingerol on the enzymatic activity.