Table 1 Estimated pharmacokinetic parameters.
From: Pharmacokinetics of anti-Mycobacterium avium-intracellulare disease drugs in silkworms
Drug | Silkworm state | Dose (mg/kg) | Cmax (μg/mL) | AUC (μg hour/mL) | Half-life (hour) | CL (mL/min/kg) | Vss (mL/kg) |
|---|---|---|---|---|---|---|---|
Clarithromycin | 5th instar-day 1 | 10 | 16.1 ± 4.7 | 437.5 ± 60.6 | 19.4 ± 4.0 | 0.8 ± 0.1 | 1244.3 ± 373.5 |
5th instar-day 5 | 10 | 13.6 ± 3.0 | 477.5 ± 62.9 | 21.2 ± 5.2 | 0.7 ± 0.1 | 1242.7 ± 211.6 | |
Azithromycin | 5th instar-day 1 | 10 | 41.2 ± 6.6 | 362.8 ± 67.8 | 7.5 ± 0.8 | 0.5 ± 0.1 | 154.5 ± 27.9 |
5th instar-day 5 | 10 | 41.2 ± 9.1 | 410.6 ± 37.8 | 7.5 ± 0.5 | 0.4 ± 0.04 | 159.8 ± 30.0 | |
Rifampicin | 5th instar-day 1 | 20 | 4.0 ± 1.7 | 16.0 ± 8.9 | 1.9 ± 0.4 | 24.8 ± 10.6 | 1573.5 ± 916.0 |
5th instar-day 5 | 20 | 5.4 ± 2.4 | 18.0 ± 7.0 | 2.6 ± 1.0 | 21.1 ± 10.1 | 2791.3 ± 1959.0 | |
Reference10 | 25 | 1.0 | 35.2 | 3100.0 | |||
Ethambutol | 5th instar-day 1 | 20 | 22.0 ± 3.8 | 123.0 ± 38.9 | 3.9 ± 0.4 | 2.9 ± 0.9 | 79.6 ± 39.4 |
5th instar-day 5 | 20 | 19.7 ± 1.2 | 94.1 ± 9.4 | 6.7 ± 4.2 | 3.6 ± 0.3 | 176.2 ± 48.8 | |
Clofazimine | 5th instar-day 1 | 2 | 2.6 ± 0.3 | 49.7 ± 1.6 | 29.2 ± 11.5 | 0.7 ± 0.02 | 1122.1 ± 513.0 |
5th instar-day 5 | 2 | 2.3 ± 0.2 | 81.9 ± 7.7 | 35.1 ± 14.9 | 0.4 ± 0.04 | 1130.9 ± 298.5 | |
Amikacin | 5th instar-day 1 | 20 | 58.1 ± 10.5 | 7687.2 ± 2102.7 | 92.6 ± 48.6 | 0.05 ± 0.01 | 366.2 ± 120.8 |
5th instar-day 5 | 20 | 77.7 ± 13.9 | 13,781.1 ± 5949.0 | 120.5 ± 56.5 | 0.03 ± 0.01 | 255.3 ± 40.8 |
