Table 2 Antibiotics exposure for three doses.
From: Pharmacokinetics of anti-Mycobacterium avium-intracellulare disease drugs in silkworms
Antibiotics | Dose | Cmax (μg/mL) | AUC (μg・hour/mL) |
|---|---|---|---|
Clarithromycin | 5 mg/kg | 7.6 ± 0.4 | 269.4 ± 47.0 |
10 mg/kg | 13.6 ± 5.9 | 457.2 ± 55.3 | |
20 mg/kg | 26.2 ± 3.2 | 1265.1 ± 327.4 | |
Azithromycin | 5 mg/kg | 16.7 ± 1.4 | 163.4 ± 8.1 |
10 mg/kg | 41.2 ± 39.9 | 410.6 ± 37.8 | |
20 mg/kg | 54.0 ± 4.6 | 714.3 ± 100.7 | |
Rifampicin | 10 mg/kg | 1.6 ± 0.1 | 4.7 ± 0.3 |
20 mg/kg | 4.6 ± 0.9 | 11.9 ± 0.5 | |
40 mg/kg | 9.6 ± 2.2 | 23.4 ± 0.3 | |
Ethambutol | 10 mg/kg | 8.3 ± 2.1 | 32.8 ± 11.4 |
20 mg/kg | 19.7 ± 1.2 | 94.1 ± 9.4 | |
40 mg/kg | 50.7 ± 5.8 | 155.8 ± 8.0 | |
Clofazimine | 2 mg/kg | 2.3 ± 0.2 | 79.6 ± 6.9 |
4 mg/kg | 2.3 ± 0.6 | 255.6 ± 47.9 | |
10 mg/kg | 3.0 ± 0.3 | 448.1 ± 122.3 | |
Amikacin | 5 mg/kg | 20.5 ± 1.7 | 3535.3 ± 597.2 |
10 mg/kg | 55.2 ± 2.6 | 24,647.5 ± 15,637.0 | |
20 mg/kg | 77.7 ± 13.9 | 13,781.1 ± 5949.0 |
