Table 4 Fat body/hemolymph concentration ratio.
From: Pharmacokinetics of anti-Mycobacterium avium-intracellulare disease drugs in silkworms
Time after drug infection (hour) | ||||||
|---|---|---|---|---|---|---|
Antibiotics | 2 | 4 | 6 | 9 | 24 | logP |
Clarithromycin | 5.4 ± 1.3 | 6.4 ± 0.5 | 12.5 ± 3.6 | 8.5 ± 2.4 | 16.2 ± 4.5 | 3.2 |
Azithromycin | 2.8 ± 1.3 | 4.6 ± 1.4 | 9.4 ± 1.5 | 13.1 ± 3.0 | 44.7 ± 8.2 | 3.0 |
Rifampicin | 15.8 ± 4.4 | 19.7 ± 5.7 | 47.0 ± 11.3 | 31.4 ± 4.4 | NA | 2.7 |
Ethambutol | 1.6 ± 0.31 | 5.1 ± 3.8 | 13.3 ± 4.8 | 10.4 ± 3.6 | NA | 0.4 |
Clofazimine | 11.5 ± 4.2 | 13.1 ± 0.8 | 25.2 ± 5.8 | 20.8 ± 5.0 | 33.0 ± 7.7 | 7.7 |
Amikacin | 0.4 ± 0.05 | 0.4 ± 0.04 | 0.4 ± 0.03 | 0.5 ± 0.01 | 0.6 ± 0.1 | -8.8 |
