Table 5 Antibiotics exposures with or without combination drugs.
From: Pharmacokinetics of anti-Mycobacterium avium-intracellulare disease drugs in silkworms
Antibiotics | Regimen | Cmax (μg/mL) | AUC (μg hour/mL) |
|---|---|---|---|
Clarithromycin | Single dose | 13.6 ± 3.0 | 477.5 ± 62.9 |
After five days of rifampicin treatment | 10.4 ± 1.3 | 452.4 ± 76.0 | |
Azithromycin | Single dose | 41.2 ± 9.1 | 410.6 ± 37.8 |
After five days of rifampicin treatment | 43.4 ± 5.4 | 371.2 ± 23.3 | |
Rifampicin | Single dose | 5.4 ± 2.4 | 18.1 ± 7.0 |
After five days of clarithromycin treatment | 4.3 ± 1.5 | 15.1 ± 5.3 | |
After five days of azithromycin treatment | 4.2 ± 1.6 | 14.5 ± 5.1 | |
Ethambutol | Single dose | 19.7 ± 1.2 | 94.1 ± 9.4 |
After five days of clarithromycin treatment | 23.9 ± 2.4 | 100.5 ± 16.7 | |
After five days of azithromycin treatment | 30.0 ± 5.9 | 122.6 ± 34.8 | |
After five days of rifampicin treatment | 25.5 ± 3.6 | 94.0 ± 19.9 | |
Clofazimine | Single dose | 2.3 ± 0.19 | 79.6 ± 6.9 |
After five days of clarithromycin treatment | 2.0 ± 0.52 | 85.1 ± 28.5 | |
After five days of azithromycin treatment | 1.4 ± 0.36 | 107.1 ± 35.2 | |
After five days of rifampicin treatment | 1.4 ± 0.11 | 106.1 ± 15.5 |
