Table 5 The association of liver volume associated genetic variants with MASLD and CLD (n = 239,308).

From: The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease

Outcome

Physical activity

Low (n = 28,253)

Moderate (n = 112,364)

High (n = 98,691)

pinteraction

Beta (95% CI)*

p-value

Beta (95% CI)*

p-value

Beta (95% CI)*

p-value

MASLD (ncases = 172)

 Basic

0.004 (− 0.015; 0.022)

0.707

0.012 (0.002; 0.022)

0.023

0.009 (0.0001; 0.018)

0.047

0.84

 Main

0.010 (− 0.011; 0.032)

0.346

0.007 (− 0.003; 0.018)

0.180

0.006 (− 0.002; 0.013)

0.138

0.65

 Main + BMI

0.010 (− 0.011; 0.031)

0.353

0.007 (− 0.004; 0.018)

0.195

0.005 (− 0.002; 0.013)

0.147

0.65

CLD (ncases = 371)

 Basic

0.024 (− 0.009; 0.057)

0.149

0.002 (− 0.011;0.016)

0.718

0.005 (− 0.006; 0.015)

0.387

0.44

 Main

− 0.007 (− 0.037 ;0.023)

0.659

 − 0.001 (− 0.015; 0.014)

0.911

0.004 (− 0.006 ;0.013)

0.421

0.36

 Main + BMI

 − 0.007 (− 0.037; 0.023)

0.654

 − 0.001 (− 0.015; 0.013)

0.888

0.004 (− 0.006; 0.013)

0.425

0.36

  1. The basic model (n = 239,308) was adjusted for age, sex, first 20 genetic principal components and genotyping array. Main model (n = 173,387) covariates include basic model covariates + alcohol consumption (g/day), smoking status and Townsend deprivation index. Main + BMI model (n = 173,029) covariates include those of the main model and body mass index (BMI). MASLD; metabolic dysfunction associated steatotic liver disease, CLD; chronic liver disease.
  2. *Betas and 95% CI limits were multiplied by 100 and reported as percentage.
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