Figure 6 | Scientific Reports

Figure 6

From: The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization

Figure 6

Speculated mechanism of the ALS risk related to the CC. (A) The pathway of excitotoxic information transmission from the M1 cortex through the CC to the M1' cortex and the feedback loop. This pathway may be influenced by the integrity of the CC, potentially affecting the risk of ALS. (B) corresponds to a–c in (A), where red represents excitatory stimuli or information and blue represents inhibitory stimuli or information. (C) corresponds to b–d in (A), and the color representation is the same as that in (B). CC, corpus callosum.

Back to article page