Figure 2 | Scientific Reports

Figure 2

From: Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media

Figure 2

Correlation between cartilage-degrading enzyme levels and cartilage destruction severity or BMI. (A) Histological assessment according to four parameters (cartilage structure, cellularity, safranin O staining and tidemark integrity) of the Mankin scoring system (score 0–14) on OA cartilage section indicates 3 phases: (i) mild OA (surface irregularity and loss some cartilage matrix (scores 0–4)), (ii) moderate OA (vertical clefts through the transitional and radial zone, loss of cartilage matrix, chondrocyte clustering (scores 5–8)) and (iii) severe OA (complete disorganization of surface zone, severe loss of cartilage matrix, chondrocyte clustering and hypocellularity (scores 9–12)). (B) Bar graphs showing concentration levels of cartilage degrading enzymes (MMP-1, MMP-9, MMP-13, ADAMTS-4 and ADAMTS-5) in synovial fluid of OA patients (N = 30) determined by ELISA. (C) Scattered plots showing correlation between cartilage-degrading enzyme levels and PG score (scoring from safranin-O staining parameter).

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