Table 3 Sensitivity and specificity of the ensemble model at all thresholds, by different covariates.
NDME (%) | Threshold 1 | Threshold 2 | Threshold 3 | ||||
|---|---|---|---|---|---|---|---|
Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity 95% CI) | ||
Gender | |||||||
Males | 85 (67.5) | 89.4 (80.9–95.0) | 93.4 (92.5–94.3) | 94.1 (86.8–98.1) | 84.4 (83.1–85.7) | 78.8 (68.6–86.9) | 97.0 (96.3–97.5) |
Females | 41 (32.5) | 87.8 (73.8–95.9) | 93.2 (92.1–94.3) | 87.8 (73.8–95.9) | 81.3 (79.5–82.9) | 85.4 (70.8–94.4) | 97.0 (96.2–97.7) |
Age | |||||||
≤ 65 | 56 (44.4) | 94.6 (85.1–98.9) | 95.8 (95.0–96.5) | 94.6 (85.1–98.9) | 88.4 (87.1–89.6) | 91.1 (80.4–97.0) | 98.0 (97.4–98.5) |
> 65 | 70 (55.6) | 84.3 (73.6–91.9) | 90.7 (89.6–91.8) | 90.0 (80.5–95.9) | 77.5 (75.8–79.1) | 73.0 (61.4–82.6) | 96.0 (95.2–96.7) |
Laterality | |||||||
Left eye | 61 (48.4) | 89.2 (79.1–95.6) | 94.2 (93.3–95.1) | 90.8 (81.0–96.5) | 85.5 (84.1–86.8) | 78.5 (66.5–87.7) | 97.1 (96.3–97.7) |
Right eye | 65 (51.6) | 88.5 (77.8–95.3) | 92.4 (91.3–93.4) | 93.4 (84.1–98.2) | 80.7 (79.1–82.2) | 83.6 (71.9–91.8) | 96.9 (96.2–97.6) |
BCVA, Snellen decimal: | |||||||
≤ 0.5 | 46 (36.5) | 95.7 (85.2–99.5) | 81.8 (78.9–84.4) | 97.8 (88.5–99.9) | 63.4 (60.0–66.8) | 82.6 (68.6–92.2) | 91.5 (89.4–93.4) |
> 0.5 | 76 (63.5) | 84.2 (74.0–91.6) | 95.5 (94.8–96.1) | 88.2 (78.7–94.4) | 86.9 (85.9–87.9) | 80.3 (69.5–88.5) | 98.0 (97.6–98.4) |
Type of diabetes | |||||||
1 | 6 (4.76) | 83.3 (35.9–99.6) | 95.0 (92.6–96.9) | 83.3 (35.9–99.6) | 88.7 (85.4–91.5) | 33.3 (4.33–77.7) | 97.3 (95.3–98.6) |
2 | 120 (95.2) | 89.2 (82.2–94.1) | 93.2 (92.4–93.9) | 92.5 (86.2–96.5) | 82.6 (81.5–83.7) | 83.3 (75.4–89.5) | 97.0 (96.5–97.5) |
Duration of diabetes | |||||||
≤ 15 years | 67 (53.2) | 95.5 (87.5–99.1) | 94.7 (93.9–95.4) | 97.0 (89.6–99.6) | 84.6 (83.4–85.8) | 85.1 (74.3–92.6) | 97.8 (97.3–98.3) |
> 15 years | 58 (46.8) | 81.0 (68.6–90.1) | 89.6 (87.9–91.1) | 86.2 (74.6–93.9) | 79.2 (76.9–81.3) | 75.9 (62.8–86.1) | 94.7 (93.4–95.8) |
Grade of DME | |||||||
Mild | 77 (61.1) | 84.4 (74.4–91.7) | 93.3 (92.6–94.0) | 88.3 (79.0–94.5) | 83.1 (82.1–84.1) | 74.0 (62.8–83.4) | 97.0 (96.5–97.4) |
Moderate and severe | 46 (38.9) | 97.8 (88.5–99.9) | 93.3 (92.6–94.0) | 100 (92.9–100) | 83.1 (82.1–84.1) | 93.5 (82.1–98.6) | 97.0 (96.5–97.4) |
Diabetic retinopathy | |||||||
Non-ST | 97 (77.0) | 86.6 (78.2–92.7) | 93.7 (93.0–94.4) | 90.7 (83.1–95.7) | 83.5 (82.5–84.5) | 78.4 (68.8–86.1) | 97.3 (96.8–97.7) |
ST-DR* | 28 (23.0) | 96.4 (81.7–99.9) | 51.4 (34.0–68.6) | 96.4 (81.7–99.9) | 40.0 (23.9–57.9) | 89.3 (71.8–97.7) | 62.9 (44.9–78.5) |
OCT quality of image (TopQ) | |||||||
≤ 40 | 43 (34.1) | 90.7 (77.9–97.4) | 80.8 (78.2–83.2) | 95.4 (84.2–99.4) | 61.0 (57.8–64.1) | 83.7 (69.3–93.2) | 92.3 (90.4–93.9) |
> 40 | 83 (65.9) | 88.0 (79.0–94.1) | 96.2 (95.6–96.8) | 90.4 (81.9–95.8) | 88.3 (87.2–89.2) | 79.5 (69.2–87.6) | 98.1 (97.6–98.5) |
