Figure 2
From: Baicalin target protein, Annexin A2, is a target of new antitumor drugs
Expression mechanism of cancer-promoting genes and inhibitors of apoptotic proteins by the complex of ANXA2 and S100A10. ANXA2 and S100A10 proteins form the AIIt heterotetramer complex within the cytoplasm prior to translocate to the cell surface. Once at the cell surface, AIIt acts as a receptor for tissue plasminogen activator (tPA) to mediate the activation of plasminogen to plasmin. Plasmin cleavage of a part of ANAX2 generates a peptide that activates Type I cytokine receptors. Activation of the receptors promotes the expression of cancer-promoting factors such as STAT-3 and NF-κB.
