Figure 7
From: Baicalin target protein, Annexin A2, is a target of new antitumor drugs
(a, b) In the full-length ANXA2-baicalin binding model, the N-terminal domain of ANXA2 is shown in red, the C-terminal core domain is shown in blue. On the other hand, in the structure of ANXA2 without baicalin, the N-terminal domain of ANXA2 is shown in magenta, the C-terminal core domain is shown in green. (c) Schematic diagram of the formation of the heterotetramer, AIIt. (d) Schematic diagram showing inhibition of the heterotetramer formation by baicalin. Compared to the model without baicalin, the N-terminal region is significantly bent in the model with baicalin.
