Table 5 Predictors of culture conversion at 2 months in the patients with MDR/RR/pre-XDR-TBTB.
Characteristic | Unadjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value |
---|---|---|---|---|
Age | 1.003 (0.963, 1.044) | 0.884 | ||
BMI < 18.5 kg/m2 | 0.733 (0.286, 1.883) | 0.519 | ||
Male | 1.403(0.585, 3.365) | 0.447 | ||
Ever smoker | 0.580 (0.200, 1.684) | 0.317 | ||
Diabetes mellitus | 0.379 (0.069, 2.078) | 0.264 | ||
TB treatment history | 2.615 (0.883, 7.741) | 0.083 | – | 0.509 |
Positive AFB smear at treatment initiation | 0.562 (0.230, 1.376) | 0.207 | ||
Imagining features | ||||
Lung damage | 1.235 (0.377, 4.048) | 0.727 | ||
Pulmonary atelectasis | 0.367 (0.146, 0.918) | 0.032 | – | 0.437 |
Cavity | 1.187 (0.484, 2.910) | 0.708 | ||
Bilateral disease | 0.971 (0.326, 2.889) | 0.957 | ||
Subtypes of TBTB | ||||
Inflammatory infiltration | 1.033 (0.390, 2.739) | 0.947 | ||
Ulceration necrosis | 0.754 (0.305, 1.867) | 0.542 | ||
Granulation hyperplasia | 1.029 (0.303, 3.496) | 0.964 | ||
Cicatrices stricture | 1.344 (0.490, 3.692) | 0.566 | ||
Multiple bronchi involvedunder bronchoscopy | 0.529 (0.220, 1.275) | 0.156 | – | 0.077 |
Tracheobronchial stenosis under bronchoscopy | 0.260 (0.090, 0.758) | 0.014 | – | 0.087 |
Tracheobronchial obstructionunder bronchoscopy | 0.729 (0.229, 2.322) | 0.592 | ||
Treatment | ||||
Treatment with bedaquiline | 5.431 (2.025, 14.567) | 0.001 | 13.417 (4.067, 44.260) | < 0.001 |
Treatment with delamanid | 2.483 (0.830, 7.423) | 0.104 | 9.333 (2.498, 34.878) | 0.001 |
Treatment with any FQ | 0.347 (0.124, 0.972) | 0.044 | – | 0.982 |
Treatment with linezolid | 1.464 (0.520, 4.118) | 0.470 | – | 0.082 |
Treatment with SLID | 0.573 (0.233, 1.408) | 0.224 | – | 0.685 |
Interventional therapy | 1.028 (0.274, 3.854) | 0.968 | – | 0.696 |
Surgical resection | 0.325 (0.032, 3.260) | 0.339 | – | 0.681 |