Table 6 Predictors of culture conversion at 6 months in the patients with MDR/RR/pre-XDR-TBTB.
Characteristic | Unadjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value |
---|---|---|---|---|
Age | 1.028(0.982, 1.075) | 0.241 | ||
BMI < 18.5 kg/m2 | 0.622 (0.233, 1.657) | 0.342 | ||
Male | 1.733 (0.666, 4.514) | 0.260 | ||
Ever smoker | 0.955 (0.315, 2.894) | 0.934 | ||
Diabetes mellitus | 1.225(0.222, 6.764) | 0.816 | ||
TB treatment history | 2.300 (0.803, 6.589) | 0.121 | – | 0.640 |
Positive AFB smear at treatment initiation | 0.553 (0.217, 1.410) | 0.215 | ||
Imagining features | ||||
Lung damage | 1.739 (0.437, 6.922) | 0.432 | ||
Pulmonary atelectasis | 0.694 (0.273, 1.770) | 0.445 | ||
Cavity | 1.339 (0.520, 3.449) | 0.546 | ||
Bilateral disease | 0.413 (0.107, 1.597) | 0.200 | ||
Subtypes of TBTB | ||||
Inflammatory infiltration | 2.724 (0.820, 9.050) | 0.102 | – | 0.086 |
Ulceration necrosis | 0.545 (0.211, 1.408) | 0.210 | ||
Granulation hyperplasia | 0.958 (0.261, 3.513) | 0.949 | ||
Cicatrices stricture | 0.864 (0.299, 2.496) | 0.787 | ||
Multiple bronchi involved under bronchoscopy | 0.537 (0.206, 1.398) | 0.203 | ||
Tracheobronchial stenosis under bronchoscopy | 0.243 (0.065, 0.913) | 0.036 | – | 0.144 |
Tracheobronchial obstructionunder bronchoscopy | 1.250 (0.354, 4.420) | 0.729 | ||
Treatment | ||||
Treatment with bedaquiline | 8.000 (2.160, 29.636) | 0.002 | 13.333 (3.379, 52.610) | < 0.001 |
Treatment with delamanid | 1.917 (0.565, 6.505) | 0.297 | 5.000 (1.357, 18.426) | 0.016 |
Treatment with any FQ | 0.367 (0.110, 1.220) | 0.102 | – | 0.682 |
Treatment with linezolid | 1.283 (0.440, 3.747) | 0.648 | – | 0.148 |
Treatment with SLID | 0.467 (0.170, 1.282) | 0.139 | – | 0.245 |
Interventional therapy | 1.143(0.271, 4.814) | 0.856 | – | 0.878 |
Surgical resection | 0.463 (0.062, 3.478) | 0.454 | – | 0.703 |