Table 2 Unique, dynamic, universal, and random mutations in the spike protein of JN.1 compared to the Wuhan-Hu-1 sequence.
Unique mutation | Dynamic mutation | Universal mutation | Random mutation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NTD | RBD | SD | HR1/HR2 | NTD | RBD | SD | NTD | RBD | SD | NTD | RBD | SD | FP | HR1/HR2 |
V83F | V503A | P681R | S939F | P85K | – | P681H | G142D | N440K | D614G | T19I | G339H | N764K | D796Y | Q954H |
L84K | – | M740I | V1104L | V90Y | – | – | T307Q | S477N | – | R21T | K356T | – | – | N969K |
P85L | – | – | P1162L | – | – | – | – | N501Y | – | A27S | S371F | – | – | P1143L |
F86L | – | – | – | – | – | – | – | – | – | S50L | S373P | – | – | – |
N87I | – | – | – | – | – | – | – | – | – | V127F | S375F | – | – | – |
D88V | – | – | – | – | – | – | – | – | – | F157S | T376A | – | – | – |
V90L | – | – | – | – | – | – | – | – | – | R158G | R403K | – | – | – |
Q218L | – | – | – | – | – | – | – | – | – | L212I | D405N | – | – | – |
T20L | – | – | – | – | – | – | – | – | – | V213G | R408S | – | – | – |
P26Q | – | – | – | – | – | – | – | – | – | L216F | K417N | – | – | – |
D53E | – | – | – | – | – | – | – | – | – | H245N | V445H | – | – | – |
F55L | – | – | – | – | – | – | – | – | – | A264D | G446S | – | – | – |
S60F | – | – | – | – | – | – | – | – | – | – | N450D | – | – | – |
N81S | – | – | – | – | – | – | – | – | – | – | L452W | – | – | – |
P174S | – | – | – | – | – | – | – | – | – | – | L455S | – | – | – |
A288S | – | – | – | – | – | – | – | – | – | – | N460K | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | T478K | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | N481K | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | E484K | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | F486P | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | Q498R | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | Y505H | – | – | – |
