Table 4 Unique, dynamic, universal, and random mutations in the spike protein of JN.1 as compared to the XBB sequence.
Unique mutation | Dynamic mutation | Universal mutation | Random mutation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NTD | RBD | SD | HR1/HR2 | NTD | RBD | SD | NTD | RBD | SD | NTD | RBD | SD | FP | HR1/HR2 |
A83V | N331K | – | – | A83F | T346I | – | – | – | – | R21T | I332V | E554K | H681R | S939F |
L84K | T333R | – | – | V90Y | – | – | – | – | – | A27S | K356T | A570V | – | P1143L |
P85K | N334S | – | – | – | – | – | – | – | – | S50L | I368L | P621S | – | – |
F86L | T346R | – | – | – | – | – | – | – | – | V127F | R403K | – | – | – |
N87I | F456L | – | – | – | – | – | – | – | – | Q146H | P445H | – | – | – |
D88V | Q506P | – | – | – | – | – | – | – | – | F157S | N450D | – | – | – |
V90L | P507T | – | – | – | – | – | – | – | – | R158G | L452W | – | – | – |
F92V | – | – | – | – | – | – | – | – | – | E183Q | L455W | – | – | – |
Y170E | – | – | – | – | – | – | – | – | – | L212I | N460K | – | – | – |
Q218L | – | – | – | – | – | – | – | – | – | E213G | N481K | – | – | – |
T315V | – | – | – | – | – | – | – | – | – | L216F | A484K | – | – | – |
S316C | – | – | – | – | – | – | – | – | – | H245N | S486P | – | – | – |
F318I | – | – | – | – | – | – | – | – | – | A264D | S490F | – | – | – |
– | – | – | – | – | – | – | – | – | – | – | H505Y | – | – | – |
