Table 2 Serum levels of biomarkers in 92 patients with hand-arm vibration injury according to the severity of vascular manifestations graded by ICC 0–3 V.
Biomarkers | ICC 0 V n = 47 | ICC 1 V n = 7 | ICC 2 V n = 9 | ICC 3 V n = 19 | P valuea |
|---|---|---|---|---|---|
ICAM-1 (ng/mL) | 170 (150–200) | 180 (170–210) | 170 (170–190) | 170 (150–180) | 0.59 |
MCP-1 (pg/mL) | 39 (30–57) | 41 (33–58) | 42 (32–76) | 36 (26–48) | 0.50 |
TM (ng/mL) | 5.2 (3.4–6.2) | 5.1 (4.2–7.1) | 8.7 (5.8–17) | 6.1 (4.5–12) | 0.01 |
vWf (µg/mL) | 14 (6.9–34) | 16 (7.6–23) | 19 (11–20) | 19 (16–21) | 0.007 |
CGRP (pg/mL) | < LODb (< LOD–96) | 58 (< LOD–220) | 140 (40–640) | 94 (< LOD–300) | 0.001 |
HSP27 (ng/ml) | 2.8 (2.1–4.0) | 2.8 (2.7–4.9) | 3.4 (3.2–5.5) | 3.6 (3.1–4.4) | 0.007 |
Caspase-3 (ng/mL) | 1.6 (1.0–2.5) | 2.6 (1.1–3.6) | 2.6 (1.8–24) | 1.9 (1.4–7.2) | 0.007 |
