Table 3 Associations (β with 95% confidence intervals) between log transformed values in serum biomarkers and severity of hand-arm vibration injury, estimated by Generalized Linear Models in 92 patients with hand-arm vibration injury. Statistically significant associations in bold face.

From: Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury

Biomarker

Raynaud’s phenomenon (Griffin score) n = 82

Vibration perception threshold (sensibility index) n = 92

Crude

Adjusted

Crude

Adjusted

ICAM-1

− 0.00 (− 0.01 to 0.00)

 

− 0.00 (− 0.13 to 0.14)

 

MCP-1

− 0.01 (− 0.02 to 0.00)

− 0.01 (− 0.02 to 0.00)a

− 0.21 (− 0.60 to 0.18)

− 0.25 (− 0.64 to 0.14)a

TM

0.01 (0.00–0.03)

 

− 0.26 (− 0.76 to 0.23)

 

vWf

0.01 (0.00–0.02)

0.01 (0.00–0.02)b

− 0.06 (− 0.37–0.26)

 

 Without concurrent diseases

   

− 0.23 (− 0.55 to 0.08)c

 With concurrent diseases

   

0.59 (− 0.07 to 1.3)c

HSP27

0.01 (− 0.00–0.02)

0.01(− 0.01 to 0.02)d

− 0.04 (− 0.52 to 0.43)

− 0.01 (− 0.45 to 0.46d

Caspase-3

0.03 (0.00–0.05)

0.03 (0.01–0.05)e

− 0.44 (− 1.3 to 0.47)

 

 Without concurrent diseases

   

− 1.1 (− 2.1 to 0.09)

 With concurrent disease

   

1.4 (0.28–3.1)

  1. aAdjusted for current smoking and frostbites.
  2. bAdjusted for age and concurrent diseases.
  3. cAdjusted for age.
  4. dAdjusted for age, concurrent diseases, and sex.
  5. eAdjusted for concurrent diseases.