Table 4 Serum levels of biomarkers in 92 patients with hand-arm vibration injury according to the severity of neurosensory manifestations graded by ICC 1-3N.

From: Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury

Biomarkers

ICC 1N n = 39

ICC 2N n = 36

ICC 3N n = 15

P valuea

ICAM-1 (ng/mL)

170 (150–190)

170 (160–200)

170 (150–170)

0.42

MCP-1 (pg/mL)

39 (31–54

38 (30–52)

39 (31–64)

0.76

TM (ng/mL)

5.4 (4.2–7.7)

4.5 (3.3–7.0)

6.6 (5.1–12)

0.51

vWF (µg/mL)

15 (12–19)

16 (11–22)

16 (13–19)

0.47

CGRP (pg/mL)

 < LODb (< LOD–120)

 < LOD (< LOD–170)

180 (< LOD–420)

0.04

HSP27 (ng/ml)

2.9 (2.3–4.3)

3.1 (2.4–3.8)

3.4 (3.1–5.2)

0.21

Caspase-3 (ng/mL)

1.8 (1.2–3.6)

1.7 (1.2–2.8)

2.2 (1.2–15)

0.45

  1. Median (interquartile ranges).
  2. Stage 0N is not included (n = 2).
  3. aP values in boldface denotes statistically significant associations, with Jonckheere-Tepstra trend test.
  4. bLimit of detection (LOD) 15 pg/ml.
Back to article page