Table 1 Predicted Hansen solubility parameters and extraction solvents' mixtures of the investigated drugs using linear layer design model with their extraction recovery.
Drug | Hansen D | Hansen P | Hansen H | Predicted solvents' mixture (1) | Predicted solvents' mixture (2) | Extraction recovery* |
|---|---|---|---|---|---|---|
Amlodipine | 15.398 | 4.814 | 5.879 | Ethyl acetate: TBME (60:40)* | Diethyl ether: Dichloromethane (60:40) | 92.73 ± 0.34% |
Ambrisentan | 15.904 | 5.533 | 6.250 | Dichloromethane: TBME (50:50) | Ethyl acetate: Dichloromethane (90:10)* | 55.93 ± 0.45% |
Risperidone | 15.453 | 4.901 | 5.981 | Ethyl acetate: TBME (60:40) | Dichloromethane: TBME (30:70)* | 85.29 ± 0.35% |
Indapamide | 15.557 | 5.024 | 6.208 | Ethyl acetate: TBME (70:30) | Ethyl acetate: Diethyl ether (80:20)* | 93.29 ± 0.48% |
Tenofovir alfenamide | 15.045 | 4.336 | 5.807 | Ethyl acetate: TBME (30:70) | Ethyl acetate: Diethyl ether (50:50)* | 71.95 ± 0.40% |
Oxcarbazepine | 16.129 | 5.812 | 6.553 | Ethyl acetate: Dichloromethane (80:20)* | Dichloromethane: TBME (60:40) | 88.78 ± 0.67% |
Desloratadine | 15.776 | 5.330 | 6.118 | Dichloromethane: TBME (40:60)* | Diethyl ether: Dichloromethane (50:50) | 98.63 ± 0.41% |
Saxagliptin | 15.554 | 5.021 | 6.322 | Ethyl acetate: Diethyl ether (70:30)* | Ethyl acetate: TBME (70:30) | 69.45 ± 0.60% |
Moxifloxacin | 15.845 | 5.450 | 6.389 | Ethyl acetate: Diethyl ether (90:10)* | Dichloromethane: TBME (50:50) | 86.22 ± 0.69% |
Etodolac | 15.262 | 4.595 | 5.764 | Ethyl acetate: TBME (40:60)* | Ethyl acetate: Diethyl ether (50:50) | 83.02 ± 0.31% |
Omeprazole | 15.626 | 5.120 | 6.177 | Ethyl acetate: Diethyl ether (90:10) | Ethyl acetate: TBME (80:20)* | 98% ± 0.45% |
Escitalopram | 15.324 | 4.696 | 5.723 | Ethyl acetate: TBME (50:50) | Diethyl ether: Dichloromethane (60:40)* | 87% ± 0.41% |
Sertraline | 15.598 | 5.075 | 5.917 | Diethylether:Dichloromethane (50:50) | Dichloromethane: TBME (30:70)* | 91% ± 0.48% |
Nebivolol | 15.708 | 5.257 | 6.141 | Ethyl acetate: Diethyl ether (90:10)* | Dichloromethane: TBME (40:60) | 87% ± 0.30% |
Telmisartan | 14.902 | 4.158 | 5.035 | Diethyl ether: TBME (10:90) | Ethyl acetate: Diethyl ether (30:70)* | 53% ± 0.48% |
Donepezil | 15.423 | 4.857 | 5.824 | Ethyl acetate: TBME (50:50) | Diethyl ether: Dichloromethane(60:40)* | 66% ± 0.56% |
Levofloxacin | 16.215 | 5.962 | 6.752 | Ethyl acetate: Diethyl ether (90:10) | Diethyl ether: Dichloromethane (50:50)* | 61% ± 0.24% |
Valacyclovir | 15.569 | 5.033 | 6.414 | Ethyl acetate: TBME (70:30)* | Ethyl acetate: Diethyl ether (80:20) | 92% ± 0.49% |
Linagliptin | 15.611 | 5.140 | 6.098 | Ethyl acetate: Diethyl ether (90:10)* | Ethyl acetate: TBME (80:20) | 90% ± 0.36% |
Chlorpheniramine maleate | 15.122 | 4.433 | 5.633 | Ethyl acetate: TBME (30:70)* | Ethyl acetate: Diethyl ether (40:60) | 94% ± 0.32% |
