Figure 4

BWC and FCMs. The percentage change in body weight compared to the mean baseline values is illustrated in (a) (group sizes differing from n = 8: males day 4 surgery + N n = 7; females: 6 h drug-control + NL n = 7). A significant decrease in body weight change was identified for male surgery + NL, + NLO, and female surgery + NO, + NLO mice on day 1 and female surgery + NO mice on day 2. The concentration of fecal corticosterone metabolites on day 1 (b) was significantly increased in male surgery + NO and female surgery + NO, + NLO mice (group sizes differing from n = 8: males day 1 drug-control + NO n = 7, day 4 surgery + N n = 7; females day -6 surgery and drug-control + N n = 7). (* = p < 0.05, analgesic regimen color-coded in (a); mean ± SD in (a) and (b); Two-way RM ANOVA in (a), One-way ANOVA in (b) with Bonferroni post hoc test in (a) and (b); OP = operation).