Figure 6
Histopathology. Representative histological images of the lesions within the gastric mucosa (a–d) and haired skin (e,f). Histopathological lesions of the gastric mucosa were present in 22% of the samples, without correlating to the treatment group or sex. The spectrum of histopathological findings ranged from no alterations (a) to moderate, focal, mixed cellular gastritis, covered by intact gastric mucosa (10.5%) (b), focal erosions of the epithelium (9%), accompanied by mixed intraepithelial (microabscess) and mucosal inflammation, granulation tissue formation and hyperplasia of the intact epithelium (c), to ulcerative lesion with associated inflammation (2%) (d) (example cases: (a): naive-control, male; (b): surgery + N, female; (c): drug-control + NL, male; (d): drug-control + NO, male. Please note that the histopathological lesions shown here are not representative for distinct experimental treatment groups.). Skin lesions were frequently present in mice that were subcutaneously injected with BUP-Depot (69%). Unaltered skin of a female naive-control mouse (e). Focally extensive, mild to moderate, mixed cellular panniculitis, in the injection site of a drug-control + NLO mouse (f). (FFPE, Hematoxylin and eosin (HE); Scale bars = 250 μm).
