Table 1 Trypanocidal cytotoxic activity and selectivity index on epimastigotes, Vero and macrophage cells of the active sesquiterpenoids.

From: New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi

Compounds

T. cruzi

Vero cell

Macrophage

IC50/24 h [µg/mL]1

IC50/24 h [µM]

CC50 [µM]2

SI3

CC50 [µM]2

SI3

BNZ

126.6

486

142

0.29

  

DhL

0.52

2.179

14

6.6

30

14.3

DC-X2

1.11

3.37

    

DC-X3

1.46

4.15

    

DC-X4

2.88

9.93

    

DC-X5

3.96

11.4

    

DC-X6

2.67

7.30

    

DC-X7

20.56

71.0

    

DC-X8

5.00

13.6

    

DC-X9

2.70

6.50

    

DC-X10

4.30

11.7

    

DC-X11

8.00

26.1

    
  1. 1IC50 Inhibitory concentration that inhibits 50% of the growth of the tested parasite.
  2. 2CC50 Cytotoxic concentration that reduces cell viability by 50%
  3. 3SI Selectivity index (CC50 /IC50).
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