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Figure 1

From: CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer

Figure 1

The CHD4 R975H mutation occurs frequently in endometrial cancer. (A) Somatic mutation frequency of CHD4 in endometrial cancer patients in cBioPortal database. (B) Alteration frequency of CHD4 in various endometrial cancer datasets. (C) The corresponding number of samples with various CHD4 mutations. (D) Location of CHD4 R975H mutation on CHD4 schematic figure. (E,F) Prediction of the impact of the CHD4 R975H mutation on protein structure and function via two bioinformatics tools. (E) Polymorphism phenotyping v2. (F) Sorting intolerant from tolerant. (G) Prediction of CHD4 structural alteration induced by R975H mutation. Upper: Overall structure of CHD4 ATPase domain lobe 2. Middle: Detailed structure and interaction between 975R and 1182E in CHD4 WT. Lower: Detailed structure of 975H and 1182E in CHD4 R975H.

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