Figure 3 | Scientific Reports

Figure 3

From: CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer

Figure 3

The CHD4 R975H mutant induces a cancer-specific transcriptome change in endometrial cancer cells. (A) Heatmap of gene expression profile of RNA-Seq result. (B) DEG volcano plot of RNA-Seq result. Differentially expressed genes (DEGs) are identified as | log2 fold change |> 0.5, p < 0.05. (C) Summary of GSEA results based on KEGG legacy gene sets, hallmark gene sets and GO molecular function gene sets. (D) GSEA results for Myc targets, mTOR signaling, TGF-β signaling, KRAS signaling, the p53 pathway, TNF-α signaling via NF-κB, growth factor signaling and EGFR signaling.

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