Table 1 Comparison of general data, related scores, and laboratory indexes of patients with sepsis complicated with SAD between the modeling and verification groups.
Item | Modeling group | Validation group | ||||||
|---|---|---|---|---|---|---|---|---|
Survival group (516 patients) | Mortality group (82 patients) | Ζ/χ2 value | P-value | Survival group (169 patients) | Mortality group (100 patients) | t/ Ζ/χ two-value | P-value | |
Sex | ||||||||
Male | 304 (84.9%) | 54 (5.1%) | 122 (61.3%) | 77 (38.7%) | ||||
Female | 212 (88.3%) | 28 (11.7%) | 1.418 | 0.234 | 47 (67.1%) | 23 (32.9%) | 0.755 | 0.385 |
Age (years) | 69 (56, 81) | 60 (44, 70) | −4.491 | < 0.001 | 54.71 ± 14.17 | 58.81 ± 16.24 | −2.170 | 0.031 |
Complication | ||||||||
Myocardial infarction | 98 (89.9%) | 11 (10.1%) | 1.447 | 0.224 | 9 (64.3%) | 4 (35.7%) | 0.240 | 0.624 |
Heart failure | 162 (91.5%) | 15 (8.5%) | 5.829 | 0.016 | 11 (50%) | 11 (50%) | 1.687 | 0.194 |
Cerebrovascular disease | 75 (83.3%) | 15 (16.7%) | 0.781 | 0.377 | 14 (66.7%) | 7 (33.3%) | 0.144 | 0.704 |
Diabetes with chronic comorbidities | 50 (84.7%) | 9 (15.3%) | 0.132 | 0.717 | 19 (42.2%) | 26 (57.8%) | 9.822 | 0.002 |
Malignant tumor | 78 (84.8%) | 14 (15.2%) | 0.208 | 0.648 | 14 (43.8%) | 18 (56.2%) | 5.659 | 0.017 |
Severe liver disease | 31 (77.5%) | 9 (22.5%) | 2.798 | 0.094 | 21 (65.5%) | 11 (34.4%) | 0.122 | 0.727 |
Scoring system | ||||||||
Acute physiology score (points) | 49 (38, 66) | 60 (48, 83) | −4.627 | < 0.001 | 31 (18, 49) | 59 (30, 75) | −6.200 | < 0.001 |
SAPS II (points) | 37 (29, 47) | 39 (28, 48) | −0.158 | 0.875 | 28.69 ± 17.01 | 37.39 ± 18.23 | −3.947 | < 0.001 |
SOFA score (points) | 6 (4, 8) | 7 (5, 10) | −3.869 | < 0.001 | 11 (8, 13) | 13 (9, 15) | −2.505 | 0.012 |
Co-morbidity index (points) | 6 (4, 8) | 6 (4, 8) | −1.199 | 0.231 | 1 (1, 2) | 2 (1, 3) | −1.845 | 0.065 |
Laboratory index | ||||||||
pH value | 7.37 (7.33, 7.42) | 7.36 (7.33, 7.42) | −0.896 | 0.370 | 7.40 (7.33, 7.45) | 7.40 (7.34, 7.46) | −0.315 | 0.753 |
Total ICU stay (days) | 3 (2, 6) | 15 (5, 27) | −9.128 | < 0.001 | 4 (2, 7) | 15 (10, 20) | −3.717 | < 0.001 |
Lactic acid (mmol/L) | 2.17 (1.60, 2.17) | 2.17 (1.50, 2.34) | −0.041 | 0.967 | 1.70 (1.20, 2.55) | 1.90 (1.30, 3.40) | −1.248 | 0.212 |
PaO2 (mmHg) | 170 (129, 177) | 170 (121, 193) | −0.553 | 0.580 | 112 (84.5, 143.5) | 101 (78, 144) | −1.284 | 0.199 |
PaCO2 (mmHg) | 42 (39, 42) | 42 (37, 44) | −0.464 | 0.643 | 31 (27.5, 37.9) | 32 (25, 36.9) | −0.115 | 0.908 |
Creatinine (μmol/L) | 24.8 (23.5, 25.0) | 24.8 (22.6, 25.9) | −0.119 | 0.905 | 93 (63, 199) | 101 (78, 253) | −1.198 | 0.231 |
Sodium (mmol/L) | 138.5 (136.0, 141.0) | 138.8 (136.5, 141.4) | −0.150 | 0.880 | 136 (131, 142) | 138 (132, 143) | −0.896 | 0.370 |
Potassium (mmol/L) | 4.15 (3.85, 4.55) | 4.08 (3.66, 4.40) | −1.688 | 0.091 | 3.8 (3.40, 4.20) | 4 (3.58, 4.40) | −2.441 | 0.015 |
Platelets (10^9/L) | 190 (133, 254) | 187 (110, 239) | −1.227 | 0.220 | 168 (95, 258) | 176 (74, 242) | −0.493 | 0.622 |
WBC (10^9/L) | 11.0 (8.0, 14.6) | 12.4 (8.6, 17.2) | −1.656 | 0.098 | 12 (7.9, 16.8) | 12.48 (8.7, 18.4) | −1.235 | 0.217 |
Albumin (g/dL) | 3.18 (3.18, 3.30) | 3.18 (2.70, 3.18) | −4.030 | < 0.001 | 2.89 (2.56, 3.55) | 2.93 (2.48, 3.37) | −0.377 | 0.706 |
Neutrophils (10^9/L) | 10.3 (6.8, 11.5) | 10.3 (8.1, 10.5) | −0.782 | 0.434 | 9.5 (5.3, 14.6) | 10.6 (5.8, 10.6) | −1.596 | 0.111 |
INR | 1.30 (1.10, 1.48) | 1.30 (1.11, 1.50) | −0.186 | 0.852 | 1.17 (1.03, 1.36) | 1.24 (1.08, 1.57) | −1.899 | 0.058 |
PT (s) | 14.1 (12.7, 16.2) | 14.4 (12.7, 16.7) | −0.013 | 0.990 | 13.5 (12, 15.9) | 15 (12.6, 18.4) | −2.644 | 0.008 |
aPTT (s) | 35 (29, 46) | 29 (26, 37) | −3.894 | < 0.001 | 32 (29, 37) | 34 (30, 38) | −1.425 | 0.154 |
ALT (U/L) | 76 (22, 106) | 57 (21, 106) | −0.627 | 0.531 | 32 (17.6, 101) | 33.4 (20, 59) | −0.367 | 0.714 |
Alkaline phosphatase (U/L) | 104 (73, 104) | 104 (72, 105) | −0.491 | 0.623 | 61.4 (53.4, 87.7) | 65.1 (54.4, 93.6) | −1.261 | 0.207 |
AST (U/L) | 90 (32, 182) | 131 (30, 182) | −0.647 | 0.518 | 52.5 (28.4, 152) | 42.8 (28, 115.3) | −0.463 | 0.643 |
Total bilirubin (mg/dL) | 1.52 (0.50, 1.66) | 1.66 (0.70, 1.66) | −2.102 | 0.036 | 1.13 (0.82, 2.09) | 1.6 (0.96, 3.03) | −0.022 | 0.008 |
Hemoglobin (g/dL) | 9.60 (8.20, 11.50) | 8.90 (7.70, 10.63) | −2.443 | 0.015 | 10.8 (8.2, 13.3) | 9.7 (7.6, 13.3) | −2.024 | 0.252 |
