Table 2 Impact of PRS on the risk of CKD.

From: Impact of hyperuricemia on CKD risk beyond genetic predisposition in a population-based cohort study

Group

Model 1

Model 2

OR (95% CI)

P-value

aOR (95% CI)

P-value

PRS 1st tertile

0.78 (0.76, 0.81)

< 0.001

0.93 (0.89, 0.97)

< 0.001

PRS 2nd tertile

Reference

Reference

PRS 3rd tertile

1.31 (1.27, 1.35)

< 0.001

1.12 (1.08, 1.17)

< 0.001

  1. Model 1. Non-adjusted.
  2. Model 2. Adjusted with age, sex, body mass index, smoking status, comorbidities (hypertension, diabetes, cardiovascular disease), physical activity, laboratory findings (hemoglobin, serum glucose, albumin, calcium, cholesterol, estimated glomerular filtration rate), hyperuricemia, PC1 ~ 10.
  3. CKD, chronic kidney disease; PRS, polygenic risk score; OR, odds ratio; aOR, adjusted odds ratio; CI, confidence interval.
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