Table 1 Eight hub genes and their functions.
Gene symbol | Describe | Function |
|---|---|---|
Col4a1 | Collagen Type IV Alpha 1 Chain | Type IV collagen proteins are integral components of basement membranes |
Lamc1 | Laminin Subunit Gamma 1 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis |
Itga10 | Integrin Alpha-10 | They participate in cell adhesion as well as cell-surface-mediated signaling |
Hapln1 | Hyaluronan And Proteoglycan Link Protein 1 | It is predicted to enable hyaluronic acid binding activity, to be an extracellular matrix structural constituent conferring compression resistance. And it is predicted to be involved in skeletal system development |
Col10a1 | Collagen Type X Alpha 1 Chain | This gene is a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification |
Tln2 | Talin 2 | It is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton |
Hexb | Hexosaminidase Subunit Beta | Related to hydrolase activity |
St3gal5 | ST3 Beta-Galactoside AlphA-2,3-Sialyltransferase 5 | The protein encoded by this gene is a type II membrane protein |
