Table 2 Association of SII with Cardiovascular-Kidney-Metabolic Syndrome and its components.

From: Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome

Characteristic

Model 1

Model 2

Model 3

OR (95%CI)

p

OR (95%CI)

p

OR (95%CI)

p

Cardiovascular-kidney-metabolic syndrome

 Continuous SII/1000

2.02 (1.70, 2.40)

 < 0.0001

1.58 (1.27, 1.96)

 < 0.0001

1.48 (1.20, 1.81)

 < 0.001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.28 (1.04, 1.57)

0.020

1.19 (1.05, 1.36)

0.010

1.19 (1.04, 1.36)

0.010

 SII-Q3

1.49 (1.22, 1.81)

 < 0.001

1.41 (1.22, 1.63)

 < 0.0001

1.40 (1.21, 1.62)

 < 0.0001

 SII-Q4

2.19 (1.79, 2.68)

 < 0.0001

1.65 (1.45, 1.89)

 < 0.0001

1.60 (1.39, 1.83)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Elevated waist circumference

 Continuous SII/1000

2.04 (1.74, 2.40)

 < 0.0001

1.49 (1.26, 1.75)

 < 0.0001

1.51 (1.28, 1.79)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.40 (1.26, 1.54)

 < 0.0001

1.36 (1.21, 1.52)

 < 0.0001

1.36 (1.21, 1.53)

 < 0.0001

 SII-Q3

1.85 (1.66, 2.06)

 < 0.0001

1.67 (1.49, 1.88)

 < 0.0001

1.68 (1.50, 1.89)

 < 0.0001

 SII-Q4

2.16 (1.95, 2.41)

 < 0.0001

1.75 (1.56, 1.96)

 < 0.0001

1.78 (1.58, 2.00)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Elevated triglycerides

 Continuous SII/1000

1.29 (1.15, 1.45)

 < 0.0001

1.15 (1.02, 1.30)

0.020

1.07 (0.96, 1.20)

0.220

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.23 (1.09, 1.38)

 < 0.001

1.16 (1.03, 1.31)

0.020

1.15 (1.01, 1.30)

0.030

 SII-Q3

1.43 (1.27, 1.62)

 < 0.0001

1.32 (1.16, 1.50)

 < 0.0001

1.28 (1.12, 1.46)

 < 0.001

 SII-Q4

1.51 (1.35, 1.69)

 < 0.0001

1.36 (1.21, 1.54)

 < 0.0001

1.27 (1.12, 1.45)

 < 0.001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.001

Low HDL-C

 Continuous SII/1000

1.47 (1.29, 1.67)

 < 0.0001

1.43 (1.26, 1.62)

 < 0.0001

1.33 (1.18, 1.51)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.18 (1.06, 1.32)

0.004

1.15 (1.03, 1.28)

0.010

1.15 (1.02, 1.28)

0.020

 SII-Q3

1.49 (1.33, 1.68)

 < 0.0001

1.45 (1.29, 1.63)

 < 0.0001

1.43 (1.27, 1.61)

 < 0.0001

 SII-Q4

1.58 (1.39, 1.80)

 < 0.0001

1.52 (1.34, 1.73)

 < 0.0001

1.44 (1.27, 1.64)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Elevated fasting plasma glucose

 Continuous SII/1000

1.80 (1.56, 2.08)

 < 0.0001

1.58 (1.35, 1.86)

 < 0.0001

1.55 (1.32, 1.83)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.07 (0.94, 1.22)

0.290

1.10 (0.95, 1.26)

0.200

1.10 (0.95, 1.27)

0.200

 SII-Q3

1.31 (1.15, 1.48)

 < 0.0001

1.26 (1.09, 1.45)

0.002

1.26 (1.09, 1.45)

0.002

 SII-Q4

1.62 (1.44, 1.82)

 < 0.0001

1.50 (1.33, 1.70)

 < 0.0001

1.49 (1.31, 1.68)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Elevated blood pressure

 Continuous SII/1000

1.97 (1.70, 2.28)

 < 0.0001

1.77 (1.49, 2.11)

 < 0.0001

1.75 (1.46, 2.10)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.09 (0.99, 1.21)

0.080

1.15 (1.01, 1.30)

0.040

1.16 (1.01, 1.32)

0.030

 SII-Q3

1.37 (1.24, 1.51)

 < 0.0001

1.35 (1.19, 1.54)

 < 0.0001

1.36 (1.19, 1.55)

 < 0.0001

 SII-Q4

1.77 (1.58, 1.98)

 < 0.0001

1.73 (1.52, 1.97)

 < 0.0001

1.73 (1.51, 1.97)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Cardiometabolic syndrome

 Continuous SII/1000

1.80 (1.55, 2.08)

 < 0.0001

1.48 (1.27, 1.72)

 < 0.0001

1.41 (1.21, 1.64)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.22 (1.08, 1.36)

0.001

1.19 (1.05, 1.36)

0.010

1.19 (1.04, 1.36)

0.010

 SII-Q3

1.54 (1.35, 1.74)

 < 0.0001

1.41 (1.22, 1.63)

 < 0.0001

1.40 (1.21, 1.62)

 < 0.0001

 SII-Q4

1.90 (1.67, 2.15)

 < 0.0001

1.65 (1.45, 1.89)

 < 0.0001

1.60 (1.39, 1.83)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

Chronic kidney disease

 Continuous SII/1000

1.93 (1.67, 2.23)

 < 0.0001

1.60 (1.36, 1.87)

 < 0.0001

1.50 (1.27, 1.77)

 < 0.0001

 SII-Q1

Ref

 

Ref

 

Ref

 

 SII-Q2

1.13 (0.98, 1.30)

0.100

1.13 (0.97, 1.31)

0.110

1.16 (1.00, 1.35)

0.050

 SII-Q3

1.22 (1.06, 1.40)

0.010

1.12 (0.97, 1.29)

0.130

1.12 (0.97, 1.29)

0.120

 SII-Q4

1.73 (1.49, 2.00)

 < 0.0001

1.49 (1.28, 1.74)

 < 0.0001

1.43 (1.22, 1.68)

 < 0.0001

 p for trend

 

 < 0.0001

 

 < 0.0001

 

 < 0.0001

  1. Calculated using multivariate logistic regression analysis.
  2. Model 1: No adjustment.
  3. Model 2: Adjusted for age, sex, race.
  4. Model 3: Adjusted for age, sex, race, education level, Poverty income ratio, smoke, alcohol use, and physical activity measured in total METs per week.
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