Figure 4 | Scientific Reports

Figure 4

From: Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood–brain–barrier in a glioblastoma model

Figure 4

(A) Horizontal view of MRI images on 14, 28, 42, and 56 DPI, tumors were specified with a yellow circle. (B) Tumor volume diagram according to MRI pictures, data = mean ± SD (analysis was done only among P-PTX NPs + P-MTX NPs vs. P-PTX NPs and it was ns.) (C) Body weight changes of the animals during the study (analysis was done only among P-PTX NPs + P-MTX NPs, P-PTX NPs and sham, only sham vs. P-MTX NPs + P-PTX NPs was significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). (D) Kaplan-Meyer diagram of the survival fraction of rats (n = 6). (E) Median survival of each treatment group and control (tumor-bearing rats) (n = 6).

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