Figure 8 | Scientific Reports

Figure 8

From: Combination chemotherapy via poloxamer 188 surface-modified PLGA nanoparticles that traverse the blood–brain–barrier in a glioblastoma model

Figure 8

(A) H&E and immunohistochemistry results of p53, Ki-67, VEGF and MMP-2 factors on the control (tumor-bearing rats), P-PTX NPs, P-MTX NPs + P-PTX NPs groups (scale bar = 100 µm, the scale bars are the same in all pictures), (B) quantitative analysis of p53, Ki-67, VEGF and MMP-2 expression, (Data = mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) (C) MRI results, picture of the excised brain, and scanned image of H&E of brain slide of the rats applied in the immunohistochemistry and immunofluorescence studies.

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