Figure 3
From: Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies

MR volumetry in right inferior lateral ventricles of MMD patients. (A) Area of right inferior lateral ventricles (rILV) of each patient (P1–P4) was visualized on T1-weighted MRI measured on 1.5 Tesla (N = 1) and 3 Tesla (N = 2) MR-scanners. (B) Values of rILV volumes of patients (n = 4) and control family members (n = 5) acquired at 1.5 and 3 Tesla, plotted against age of examined subjects. (C) Cross plot indicating agreement between rILV volumes acquired at 1.5 and 3 Tesla (excellent in 4 subjects, very good in 3 subjects, moderate in 2 subjects). A slight overestimation of 1.5 Tesla compared with 3 Tesla measurements is noticeable. (D) Bland–Altman linear correlation plot (green indicates the upper and salmon the lower limit of agreement with CI, purple indicates the bias with CI) confirms an acceptable overestimation of 1.5 relative to 3 Tesla volumetry with a bias of 12 mm3 and 95% CI (− 10, 34) mm3. Abbreviations: CI, confidence interval; MMD, Miyoshi myopathy/dysferlinopathy; MR, magnetic resonance; n, number of examined subjects; N, number of repetitions. Patient/family control coding matches the pedigree coding (Fig. 1) as follows: P1 = F: I, P2 = F: III, P3 = F: VII, P4 = F: IV, and C1 = P: II, C2 = P: I, C3 = F: V, C4 = F: II, and C5 = F: VI.