Table 2 Hazards ratio of outcomes regarding surgery versus no surgery as initial treatment for patients with intrahepatic cholangiocarcinoma during 2004–2018.

From: Prognostic factors in patients with intrahepatic cholangiocarcinoma

Outcome variables

Unmatched (before propensity score matching)

Matched (after propensity score matching)

Surgery

Surgery versus no surgery

Surgery

Surgery versus no surgery

No (N = 5377)

Yes (N = 2563)

No (N = 969)

Yes (N = 969)

n (%)

n (%)

Unadjusted HR

P

Adjusted HR

P

n (%)

n (%)

Unadjusted HR

P

Adjusted HR

P

Overall survival

1335 (24.8)

1075 (41.9)

0.96 (0.88–1.03)

0.257

0.65 (0.60–0.71)

 < 0.001

221 (22.8)

341 (35.2)

0.92 (0.78–1.09)

0.348

0.69 (0.62–0.78)

 < 0.001

Cancer-specific survival

2515 (46.8)

1543 (60.2)

1.21 (1.13–1.29)

 < 0.001

0.60 (0.55–0.66)

 < 0.001

390 (40.2)

512 (52.8)

1.06 (0.93–1.21)

0.393

0.65 (0.57–0.74)

 < 0.001

Disease-free survival

148 (2.8)

1067 (41.6)

0.25 (0.21–0.30)

 < 0.001

0.45 (0.42–0.49)

 < 0.001

44 (4.5)

295 (30.4)

0.34 (0.24–0.46)

 < 0.001

0.54 (0.48–0.60)

 < 0.001

Local recurrence

224 (4.2)

1330 (51.9)

0.24 (0.21–0.28)

 < 0.001

0.38 (0.35–0.41)

 < 0.001

59 (6.1)

397 (41.0)

0.28 (0.21–0.37)

 < 0.001

0.46 (0.41–0.51)

 < 0.001

  1. HR: hazard ratio; CI: confidence interval.