Table 3 Case by case analysis of patients with weaning failure.

From: Weaning from mechanical ventilation during myasthenic crisis, a monocentric retrospective study

Age Sex

Delay (mo)

MV Duraiton

SBT duration

Unfavorable criteria

MM Score

Axial tonus

Swallowing disorder

Reason for failure

52M

inaugural

9

8

N

37

10

O

Swallowing disorder with massive pulmonary aspiration

83M

48

36

8

N

35

10

N

Failure at 4th day. Plurifactorial reason sarcopenia, NMAW

43M

Inaugural

48

8

O

47

0

O

Swallowing disorder with massive pulmonary aspiration

81M

3

6

8

N

22

5

O

Swallowing disorder with massive pulmonary aspiration

28F

9

6

8

O

27

10

N

Laryngeal Edema

19F

36

5

8

O

70

10

O

Swallowing disorder with massive pulmonary aspiration

80F

30

18

8

O

18

0

N

Early respiratory exhaustion attributed to bad myasthenic control despite successful SBT and functional tests

87F

Inaugural

18

4

O

ND

ND

N

Early respiratory exhaustion attributed to bad myasthenic control despite successful SBT and functional tests

39F

Inaugural

13

8

O

50

10

O

Swallowing disorder with massive pulmonary aspiration

60F

8

12

8

N

50

10

N

Laryngeal Edema

36F

Inaugural

20

5

O

ND

ND

N

Failure 24 h after auto-extubation despite 4-h successful spontaneous breathing trial. Medical history of cardiac failure, plurifactoorial failure

72F

5

27

8

O

36

5

N

Respiratory exhaustion despite physiotherapy and NIV use. Extubation with widened criteria (VC drop from 39 to 16% and RR increasing from 22 to 30 bpm. Widened criterion due to age and inability to perform prolonged SBT

22F

2

13

8

N

38

5

O

Swallowing disorder with massive pulmonary aspiration

76M

Inaugural

24

8

N

ND

ND

N

Undefined reason for extubation failure

69M

25

16

4

O

47

10

N

Early respiratory exhaustion attributed to bad myasthenic control despite successful 4-h SBT. Duration lowered due to a satisfactory apparent myasthenic control

61F

432

22

8

N

20

0

N

Respiratory exhaustion despite physiotherapy NIV and cough assist. Thymoma relapse

64M

Inaugural

15

10

O

ND

ND

N

Postoperative period of thymectomia. Respiratory exhaustion 48 h after extubation. Attributed to a bad myasthenia control. Successful extubated 7 days after

76M

41

34

8

N

70

5

N

Third myasthenic crisis. History of pulmonary cancer with radiotherapy. Sarcopenia. Multifactorial respiratory exhaustion

  1. MV: Mechanical Ventilation; SBT: Spontaneous Breathing Trial; MM Score: Myasthenia muscle score; NMAW: Neuromuscular acquired weakness; VC: Vital capacity; NIV: Non-invasive ventilation.