Table 4 Baseline Patient Characteristics according to weaning duration.
From: Weaning from mechanical ventilation during myasthenic crisis, a monocentric retrospective study
Weaning duration < 7 days | Weaning duration > 7 days | p | Missing | |
|---|---|---|---|---|
n | 60 | 56 | ||
Age (years old) | 64 [40, 77] | 69 [52, 77] | 0.437 | 0.0 |
Female | 22 (37.9) | 27 (48.2) | 0.358 | 1.6 |
Body mass index (kg/m2) | 25.3 [22.0, 28.2] | 24.0 [20.0, 28.1] | 0.264 | 36.5 |
Medical history | ||||
Pulmonary disease | 7 (11.9) | 11 (19.6) | 0.438 | 0.8 |
Cardiac failure | 4 (6.8) | 7 (12.5) | 0.468 | 0.8 |
Myasthenia gravis characteristics | ||||
Delay from diagnosis to onset (months) | 20.5 [2.0, 72.0] | 4.1 [1.0, 51.7] | 0.113 | 6.3 |
EMG confirmed myasthenia gravis | 26 (89.7) | 31 (91.2) | 1.000 | 45.2 |
Acetylcholine Receptor Antibody | 51 (91.1) | 51 (91.1) | 1.000 | 3.2 |
Muscle specific tyrosine kinase antibody | 2 (3.6) | 5 (8.9) | 0.435 | 3.2 |
Thymoma present | 28 (48.3) | 19 (34.5) | 0.197 | 3.2 |
Long course treatment in non-inaugural crisis | N = 40 | N = 28 | ||
Thymectomy | 18 (45.0) | 9 (32.1) | 0.364 | 0.0 |
Corticoids | 20 (50.0) | 13 (48.1) | 1.000 | 0.8 |
Other immunosuppressive drugs | 18 (45.0) | 10 (37.0) | 0.692 | 0.8 |
Corticoids and another IS drug | 13 (22.5) | 6 (22.2) | 0.523 | |
Cholinesterase inhibitors | 48 (82.8) | 38 (69.1) | 0.138 | 2.4 |
Precipitating factor | 46 (76.7) | 40 (71.4) | 0.666 | 0.0 |
Infection | 26 (43.3) | 21 (37.5) | 0.653 | 0.0 |
Upper airways | 10 (21.7) | 2 (5.0) | 0.055 | 26.2 |
Pneumonia | 13 (29.5) | 16 (41.0) | 0.387 | 28.6 |
Other | 6 (13.0) | 4 (10.0) | 0.919 | 26.2 |
Iatrogenic cause | 22 (36.7) | 14 (25.0) | 0.248 | 0.0 |
Recent surgery | 11 (23.9) | 9 (22.5) | 1.000 | 25.4 |
Treatment non-compliance | 5 (10.9) | 1 (2.5) | 0.273 | 26.2 |
Corticoids introduction | 2 (4.3) | 3 (7.5) | 0.872 | 25.4 |
Corticoids tapering | 3 (6.5) | 0 (0.0) | 0.291 | 25.4 |
Adverse event of another drug | 3 (6.5) | 3 (7.7) | 1.000 | 26.2 |
Other | 6 (13.0) | 7 (17.5) | 0.784 | 25.4 |
Signs before mechanical ventilation | ||||
MV as first sign | 33 [23, 56] | 39 [25, 58] | 0.579 | 18.3 |
Bulbar symptoms | 45 (78.9) | 49 (89.1) | 0.229 | 3.2 |
Swallowing disorder | 35 (77.8) | 37 (75.5) | 0.988 | 0.0 |
Macroscopic aspiration | 20 (47.6) | 18 (36.7) | 0.403 | 7.9 |
Oculomotor weakness | 22 (40.7) | 26 (47.3) | 0.621 | 6.3 |
Limb deficit | 39 (70.9) | 39 (72.2) | 1.000 | 5.6 |
Head lift deficit | 35 (63.6) | 29 (55.8) | 0.527 | 7.1 |
General ICU severity scores | ||||
Admission SOFA | 4 [0, 5] | 4 [1, 6] | 0.405 | 0.8 |
SAPS II | 45 [29, 52] | 53 [38, 56] | 0.045 | 18.3 |
Myasthenic crisis treatment | ||||
Feeding tube prior endotracheal intubation | 15 (28.3) | 10 (19.6) | 0.419 | 12.7 |
Corticosteroids increase | 30 (52.6) | 36 (67.9) | 0.150 | 5.6 |
Polyvalent Intravenous immunoglobulins | 32 (62.7) | 40 (80.0) | 0.090 | 15.9 |
Plasma Exchanges | 10 (19.6) | 18 (37.5) | 0.080 | 16.7 |
Both | 2 (4.0) | 14 (29.2) | 0.002** | 19.0 |
None | 59 (100.0) | 55 (100.0) | NA | 2.4 |
Delay between IgIV and extubation | 11 [8, 17] | 18 [13, 34] | 0.018* | 65.9 |
Delay between PE and extubation | 19 [8, 22] | 12 [10, 17] | 0.668 | 87.3 |
NIV before intubation | 5 (10.6) | 8 (17.8) | 0.494 | 24.6 |
Mechanical ventilation duration before first SBT | 8 [4, 14] | 12 [5, 25] | 0.069 | 5.6 |
ICU Adverse events | ||||
Ventilator acquired pneumonia | 10 (17.5) | 20 (36.4) | 0.042* | 5.6 |
Septic Shock | 2 (3.5) | 3 (5.6) | 0.951 | 4.8 |
Acute respiratory distress syndrome | 2 (3.5) | 2 (3.7) | 1.000 | 4.8 |
Other | 6 (10.5) | 19 (34.5) | 0.005** | 4.0 |
Outcome | ||||
ICU length of stay (days) | 17 [13, 29] | 29 [18, 39] | < 0.001*** | 11.9 |
Hospital length of stay (days) | 34 [23, 51] | 48 [33, 71] | 0.005** | 11.9 |
Mortality | 1 (1.8) | 2 (3.6) | 0.975 | 4.8 |
