Figure 4
The establishment and external validation of the T cell-related genes signature. (A) Lasso regression profiles of TRGS to prevent over-fitting and tenfold cross-validation of variable selection with Lasso. (B) Coefficients of 6 T cell-related genes finally obtained in stepwise Cox regression. (C, E, G) Kaplan–Meier curves illustrating the prognostic value of TRGS. (D, F, H) Time-dependent ROC curves demonstrating the prognostic signature's predictive performance. (I) Nomogram integrating age, stage, and TRGS for prognosis assessment. (J) The calibration curve of the constructed nomogram of 1-year, 3-years, and 5-years survival prediction. (K) Decision curve analysis evaluating the 5-years survival benefit in the TCGA cohort. (L) Univariate and multivariate COX regression analysis of TRGS and various clinical features in TCGA cohort.
