Figure 2
From: Cryopreserved nanostructured fibrin-agarose hydrogels are efficient and safe hemostatic agents
Efficacy and short-term safety study of Cryo-NFAH. (A) Time to reach hemostasis by application of hemostatic agents in a severe liver resection model (1.5 cm liver incision). Results are presented as ± SEM, Mann–Whitney U test (p > 0.99). (B) Percentage of rats with hepatic hematoma 24 h after treatment application. (C) Adhesion grade of hemostatic agents. Adhesion in each sample was scored from 0 to 2: 0, no adhesion; 1, thin adhesion separable by gravity; and 2, thick adhesion not separable by gravity. (D) Levels of inflammatory factors in blood from rats subjected to liver resection and treated with hemostatic agents at the moment of sacrifice (24 h): C-reactive protein (CRP), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). Data represent mean ± SEM and were analyzed using (N = X–Y); *p < 0.05; **p < 0.01, ***p < 0.001. (E) Histopathological variables of animals treated with NFAH and Cryo-NFAH after partial hepatectomy.
