Table 1 Baseline characteristics.

From: Simultaneous removal of endotoxins, inflammatory mediators and uremic toxins in ICU patients with septic shock: a retrospective cohort study

Variable

Study population (n = 117)

Matched cohort (n = 42)

RRT (n = 96, 82%)

RRT + HA (n = 21, 18%)

Total (n = 117, 100%)

SMD

p (two-tailed)

RRT (n = 21 (50%)

RRT + HA (n = 21, 50%)

Total (n = 42, 100%)

SMD

p (two-tailed)

Sex

Female

30 (31%)

8 (38%)

38 (33%)

0.145

0.61 a

6 (29%)

8 (38%)

14 (33%)

0.177

0.69 d

Male

66 (69%)

13 (62%)

79 (67%)

15 (71%)

13 (62%)

28 (67%)

Age (years)

NA

68.5 (16.0) [65.3–69.9]

58.0 (20.0) [52.4–64.0]

67.0 (16.0) [63.7–68.1]

0.810

0.002 b

60.1 ± 15.1 [53.2–67.0]

58.2 ± 12.7 [52.4–64.0]

59.1 ± 13.8 [54.8–63.5]

0.106

0.55 e

Height (cm)

NA

174.1 ± 10.8 [172.0–176.3]

175.7 ± 10.1 [171.1–180.3]

174.4 ± 10.6 [172.5–176.3]

0.145

0.55 c

177.6 ± 12.3 [172.0–183.2]

175.7 ± 10.1 [171.1–180.3]

176.6 ± 11.1 [173.2–180.1]

0.041

0.59 e

Weight (kg)

NA

85.0 (29.8) [82.7–92.5]

85.0 (32.5) [79.1–104.7]

85.0 (29.5) [83.8–92.9]

0.173

0.66 b

80.0 (31) [70.5–92.4]

85.0 (32.5) [79.1–104.7]

82.5 (36.0) [78.4–94.9]

0.452

0.10 f.

BMI (kg/m2)

NA

27.6 (9.0) [27.4–30.6]

26.6 (11.0) [25.7–33.6]

27.5 (9.0) [27.6–30.6]

0.087

0.90 b

24.2 (8.8) [22.4–29.3]

26.6 (11.0) [25.7–33.6]

25.6 (7.8) [25.2–30.4]

0.445

0.09 f.

Smoker

Non-smoker

57 (60%)

15 (71%)

72 (61%)

0.124

0.80 a

14 (67%)

15 (71%)

29 (69%)

0.085

 > 0.99 d

Ever smoker

30 (31%)

6 (29%)

36 (31%)

5 (24%)

6 (29%)

11 (26%)

unknown

9 (9%)

0 (0%)

9 (8%)

2 (9%)

0 (0%)

2 (5%)

Alcohol abuse

No abuse

71 (74%)

19 (91%)

90 (77%)

0.116

 > 0.99 a

15 (71%)

19 (91%)

34 (80%)

0.071

 > 0.99 d

Abuse

11 (11%)

2 (9%)

13 (11%)

2 (10%)

2 (9%)

4 (10%)

unknown

14 (15%)

0 (0%)

14 (12%)

4 (19%)

0 (0%)

4 (10%)

Coronary heart disease

no

61 (63%)

17 (81%)

78 (67%)

0.370

0.20 a

15 (71%)

17 (81%)

32 (76%)

0.177

0.69 d

Yes

35 (37%)

4 (19%)

39 (33%)

6 (29%)

4 (19%)

10 (24%)

Arterial hypertension

No

31 (32%)

9 (43%)

40 (34%)

0.266

0.31 a

12 (57%)

9 (43%)

21 (50%)

0.156

0.73 d

Yes

65 (68%)

11 (52%)

76 (65%)

9 (43%)

11 (52%)

20 (48%)

unknown

0 (0%)

1 (5%)

1 (1%)

0 (0%)

1 (5%)

1 (2%)

Heart failure

No

84 (88%)

18 (86%)

102 (87%)

0.053

0.73 a

19 (91%)

18 (86%)

37 (88%)

0.253

 > 0.99 d

Yes

12 (12%)

3 (14%)

15 (13%)

2 (9%)

3 (14%)

5 (12%)

Cardiomyopathy

No

89 (93%)

19 (91%)

108 (92%)

0.083

0.66 a

18 (86%)

19 (91%)

37 (88%)

0.124

 > 0.99 d

Yes

7 (7%)

2 (9%)

9 (8%)

3 (14%)

2 (9%)

5 (12%)

Heart defects (vitium)

None, or corrected

86 (90%)

19 (91%)

105 (90%)

0.029

 > 0.99 a

17 (81%)

19 (91%)

36 (86%)

0.177

0.69 d

Non-corrected pathological

10 (10%)

2 (9%)

12 (10%)

4 (19%)

2 (9%)

6 (14%)

Arrhythmia

No

75 (78%)

18 (86%)

93 (80%)

0.187

0.56 a

18 (86%)

18 (86%)

36 (86%)

0.177

 > 0.99 d

Yes (atrial fibrillation)

21 (22%)

3 (14%)

24 (20%)

 

3 (14%)

3 (14%)

6 (14%)

 

Past myocardial infarction

No

88 (92%)

21 (100%)

109 (93%)

0.330

0.35 a

19 (91%)

21 (100%)

40 (95%)

0.317

0.50 d

Yes

8 (8%)

0 (0%)

8 (7%)

2 (9%)

0 (0%)

2 (5%)

Past cardiac transplant

No

96 (100%)

19 (91%)

115 (98%)

0.759

0.03 a

21 (100%)

19 (91%)

40 (95%)

0.317

0.50 d

Yes

0 (0%)

2 (9%)

2 (2%)

0 (0%)

2 (9%)

2 (5%)

Renal insufficiency

Acute

59 (61%)

17 (81%)

76 (65%)

0.410

0.13 a

16 (76%)

17 (81%)

33 (79%)

0.071

 > 0.99 d

Chronic (incl. acute-on-chronic)

37 (39%)

4 (19%)

41 (35%)

5 (24%)

4 (19%)

9 (21%)

History of tumor disease

No

51 (53%)

18 (86%)

69 (59%)

0.679

0.007 a

15 (71%)

18 (86%)

33 (79%)

0.299

0.38 d

Yes

45 (47%)

3 (14%)

48 (41%)

6 (29%)

3 (14%)

9 (21%)

Diabetes

No

64 (67%)

16 (76%)

80 (68%)

0.204

0.45 a

11 (52%)

16 (76%)

27 (64%)

0.340

0.23 d

Yes (any type)

32 (33%)

5 (24%)

37 (32%)

10 (48%)

5 (24%)

15 (36%)

SOFA (admission to ICU)

NA

14.0 (4.0) [12.5–13.8]

13.0 (5.0) [11.3–14.2]

14.0 (4.0) [12.5–13.6]

0.110

0.61 b

12.5 ± 3.5 [10.9–14.1]

12.8 ± 3.1 [11.3–14.2]

12.6 ± 3.3 [11.6–13.6]

0.110

0.77 e

APACHE (admission to ICU)

NA

36.0 (9.0) [33.5–36.3]

34.0 (9.0) [30.0–35.8]

35.0 (9.0) [33.3–35.8]

0.293

0.15 b

32.3 ± 8.0 [28.7–36.0]

32.9 ± 6.4 [30.0–35.8]

32.6 ± 7.2 [30.4–34.9]

0.250

0.80 e

SAPS II (admission to ICU)

NA

81.5 (23.0) [74.8–81.3]

72.0 (15.0) [66.5–79.1]

79.0 (22.0) [74.2–80,0]

0.334

0.11 b

69.5 ± 17.2 [61.7–77.3]

72.8 ± 13.8 [66.5–79.1]

71.1 ± [66.3–76.0]

0.151

0.44 e

  1. Results are reported as n (%), mean ± SD, or median (IQR) with [95% CI]. Normal/non-normal distribution was verified using Shapiro-Wilk’s test, and the following tests used as appropriate – a, Fisher’s exact test; b, Mann-Whitney-U-Test; c, t-test (independent samples); d, McNemar’s test; e, Paired t-test; f, Wilcoxon signed-rank test. Exact significance is reported. SMD, standardized mean difference.
  2. Medium effect sizes (i.e., SMD > 0.5) and p-values < 0.05 are shown boldunderline.
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