Fig. 4

Impaired social behaviors of KDM6B mKO animals. (A) Quantification of the number of victories in the tube dominance test. Each point represents the mean of victories per day 1–4. (B) Quantification of the time spent in the 3-chamber social interaction test with the novel animal or novel object in Control and KDM6B mKO animals. (C-E) Direct social interaction test to quantify (C) nose-nose (N–N), (D) nose-head (N–H), and (E) nose-anogenital (N-A) interactions between Control or KDM6B mKO animals. Bars represents mean ± SEM. Students t-test was used to determine significance compared to control condition. *p < 0.05, **p < 0.01, n = 9 animals for Control and KDM6B mKO animals. ns = non-significant.