Fig. 4 | Scientific Reports

Fig. 4

From: G-quadruplex forming regions in GCK and TM6SF2 are targets for differential DNA methylation in metabolic disease and hepatocellular carcinoma patients

Fig. 4

HiC data analysis in HepG2 cells and in HCC tumor material visualized in 3D genome browser84. (A). TAD formation on chr. 7 around the GCK DMP in HepG2 (upper panel)82 and HCC tumor tissue (lower panel)83. (B). Analysis of potential contact points of the regulatory region (red vertical line) shows interactions (blue highlighted areas) with GCK intron 1 and an intergenic region between MYL7 and POLD2 near an enhancer region. (C). TAD formation on chr. 19 around TM6SF2 in HepG2 (upper panel)82 and HCC tumor tissue (lower panel)83. (D). Analysis of potential contact points of the regulatory region (red vertical line) shows interactions (blue highlighted areas) with SUGP1 and HAPLN4. Chromosome annotations are given in the newer assembly hg38.

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