Table 2 Histopathological factors recorded by the local and review pathologists.

From: Central pathology review and its prognostic value in upper tract urothelial carcinoma patients: a nationwide multi-institutional study

Variables

Local pathologist (N = 377)

Review pathologist (N = 377)

p-valuea

N

%

N

%

Grade

 Not mentioned

4

(1.1)

2

(0.5)

 < 0.001**

 Low grade

49

(13.0)

93

(24.7)

 

 High grade

324

(85.9)

282

(74.8)

 

Tumor location

 Renal pelvis

184

(48.8)

185

(49.1)

0.510

 Ureter

125

(33.2)

128

(34.0)

 

 Renal pelvis and ureter

68

(18.0)

62

(16.4)

 

 N/A

0

(0.0)

2

(0.5)

 

Tumor architecture

 Papillary

220

(58.4)

237

(62.9)

0.005**

 Non-papillary

81

(21.5)

83

(22.0)

 

 Mixed

59

(15.6)

55

(14.6)

 

 Not mentioned

17

(4.5)

2

(0.5)

 

Invasiveness

 Non-invasive

63

(16.7)

149

(39.5)

 < 0.001**

 Invasive

313

(83.0)

226

(59.9)

 

 Not mentioned

1

(0.3)

2

(0.5)

 

Variant histology

 Yes

31

(8.2)

111

(29.4)

 < 0.001**

 No

346

(91.8)

266

(70.6)

 

pT stage

 Tis/Ta/T0

63

(16.7)

153

(40.6)

 < 0.001**

 T1/T2

156

(41.4)

71

(18.8)

 

 T3/T4

158

(41.9)

153

(40.6)

 

Lymphovascular invasion

 Negative

282

(74.8)

249

(66.0)

0.002**

 Positive

91

(24.1)

128

(34.0)

 

 Not mentioned

4

(1.1)

0

(0.0)

 

Perineural invasion

 Negative/free

306

(81.2)

327

(86.7)

 < 0.001**

 Positive

28

(7.4)

50

(13.3)

 

 Not mentioned

43

(11.4)

0

(0.0)

 

Surgical margin status

 Free

356

(94.4)

335

(88.9)

0.01*

 Not free

18

(4.8)

40

(10.6)

 

 Not mentioned

3

(0.8)

2

(0.5)

 
  1. aChi-Squared test calculated for the difference variables. * < 0.05, ** < 0.01.