Table 4 Comparative univariate overall survival analysis of upper tract urothelial cancer patients according to local and review pathology.
Univariate analysis, overall survival | Local pathologist | Review pathologist | ||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Grade | ||||
 Low grade | 1 |  | 1 |  |
 High grade | 1.910 (0.988, 3.695) | 0.054 | 2.378 (1.385, 4.084) | 0.002** |
 Not mentioned | 1.616 (0.206, 12.649) | 0.648 | 0.000 (0.000, ) | 0.969 |
Architecture | ||||
 Papillary | 1 |  | 1 |  |
 Non-papillary | 1.474 (0.878, 2.475) | 0.142 | 1.591 (0.953, 2.657) | 0.076 |
 Mixed | 2.405 (1.475, 3.922) |  < 0.001** | 2.896 (1.823, 4.601) |  < 0.001** |
 Not mentioned | 2.338 (1.103, 4.957) | 0.027* | 0.000 (0.000, ) | 0.969 |
Invasiveness | ||||
 Non-invasive | 1 |  | 1 |  |
 Invasive | 1.837 (1.004, 3.360) | 0.048* | 2.422 (1.559, 3.764) |  < 0.001** |
 Not mentioned | 0.000 (0.000, ) | 0.969 | 0.000 (0.000, ) | 0.969 |
Variant histology | ||||
 No | 1 |  | 1 |  |
 Yes | 1.850 (1.051, 3.258) | 0.033* | 2.131 (1.424, 3.187) |  < 0.001** |
pT stage | ||||
 Tis/Ta/T0 | 1 |  | 1 |  |
 T1/T2 | 1.134 (0.566, 2.270) | 0.723 | 1.195 (0.618, 2.309) | 0.596 |
 T3/T4 | 3.207 (1.683, 6.113) |  < 0.001** | 3.418 (2.160, 5.406) |  < 0.001** |
LVI | ||||
 Negative/free | 1 |  | 1 |  |
 Positive | 2.201 (1.453, 3.335) |  < 0.001** | 3.297 (2.208, 4.923) |  < 0.001** |
 Not mentioned | 5.033 (1.574, 16.093) | 0.006** |  |  |
PNI | ||||
 Negative/free | 1 |  | 1 |  |
 Positive | 4.337 (2.566, 7.330) |  < 0.001** | 4.134 (2.660, 6.424) |  < 0.001** |
 Not mentioned | 1.339 (0.708, 2.533) | 0.369 |  |  |
Surgical margin | ||||
 Free | 1 |  | 1 |  |
 Not free | 3.744 (1.857, 7.549) |  < 0.001** | 3.803 (2.285, 6.330) |  < 0.001** |
 Not mentioned | 8.473 (2.055, 34.941) | 0.003** | 3.227 (0.446, 23.354) | 0.246 |
