Fig. 3 | Scientific Reports

Fig. 3

From: PIP-seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure

Fig. 3

ILC subsets show distinct effector gene expression in response to Alt with BPC. (A) Gene expression of NK1.1 (Klrb1c), T-bet (Tbx21), EOMES, NCR1, GATA3, and ST2 (Il1rl1) were used firstly to identify the type 1 and type 2 ILC subsets. (B) Type 1, type 2, type 3, inflammatory (Inflamm), and activation transcription factor markers were used to identify distinct ILC subsets. (C) The addition of BPC to Alt changes the size of ILC and NK cell clusters. (D) The addition of BPC changes the proportions of ILC subpopulations. (E) Expression of cytokines (type 1, type 2, type 3, inflammatory, TNF super family, and TGF super family) and chemokines in each ILC subset changes after the addition of BPC. (F) The expression of activation transcription factors in ILC subsets changes after the addition of BPC. (G) The overall ILC expression of selected pro-neutrophilic and tissue remodeling-associated effector genes changes after the addition of BPC.

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